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《Carcinogenesis,Teratogenesis & Mutagenesis》 2008-04
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Selenium-enriched Garlic on the Gastric Juice Components and Upper Gastrointestinal Tract Stimulation in Experimental Animal

LIN Fei1,LIANG Yi1,LU Lian1,YANG Wen-jie2,YANG Yan-hua2(National Institute for the Control of Pharmaceutical and Biological Products,Beijing 100050;2.Institute of Nutrition and Food Safety,Chinese Center for Disease Control and Prevention,Beijng 100050,China)  
BACKGROUND AND AIM: To evaluate the effects of selenium-enriched garlic on the gastric juice components and upper gastrointestinal tract stimulation in rats and beagle dogs.MATERIALS AND METHODS: Selenium-enriched garlic was given to rats and beagle dogs for 10 days,stimulant response of the upper gastrointestinal tract and changes of the mucous membrane,gastric acid and pepsin of rat gastric juice were determined.RESULTS: The free hydrochloric acid,total acidity and activity and volume of pepsin in rats were obviously inhibited.Gastric secretion and total acidity increased at doses of 1 500 mg/kg and 3 750 mg/kg,and total acid output increased at dose of 3 750 mg/kg.There was gentle stimulation on upper gastrointestinal tract mucosa in rats treated with selenium-enriched garlic.There was gentle stimulation on upper gastrointestinal tract mucosa in beagle dogs treated repeatedly with 200 mg/kg selenium-enriched garlic;and medium stimulation in beagle dogs treated with 350 mg/kg and 450 mg/kg once.CONCLUSION: Selenium-enriched garlic could change the stomach intestine environment,suppress gastric acidity and pepsin enzymatic activity,promote gastric secretion and stimulate upper gastrointestinal tract mucosa.
【Fund】: 国家自然科学基金(30471454)
【CateGory Index】: R285.5
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