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《Carcinogenesis,Teratogenesis & Mutagenesis》 2008-04
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Protective Effects of Huangqi on Vascular Endothelial Cells Exposed to High Gluose

FAN Ke1,CHEN Pei-hong2,WU Qing3(1.Liyuan Hospital,Tongji Medical College of Huazhong University of Science and Technology,Wuhan 430000;2.Wuhan Hospital of Tradional Chinese Medicine,Wuhan 430014;3.Institute of Hematotogy Union Hospital,Tongji Medical Colllege of Huazhong University of Science and Technology,Wuhan 430022,China)  
BACKGROUND AND AIM: To evaluate the protective effects of Huangqi on the damage of high glucose on vascular endothelial cell(VEC-304)in vitro.MATERIALS AND METHODS: The model of human umbilical vein endothelial cells(VEC-304) damage was induced by 50% glucose for 4 h.The cells were pretreated with three concentrations of Huangqi solution for 24 h,before they were exposed to glucose.MTT and protein levels in cells were determined after 4 h.The expression of VEGF was investigated by RT-PCR and immunohistochemistry methods.RESULTS: MTT and protein levels in cells of the normal control group amd Huangqi-treated groups were higher than in glucose-damaged group without huangqi(P0.05).The expression of VEGF was inhibited by glucose.CONCLUSION: Huangqi could protect the damages of VEC-304 endothelial cells induced by high glucose.
【CateGory Index】: R285
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