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《Carcinogenesis,Teratogenesis & Mutagenesis》 2008-05
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Inhibitory Effects of Sulindac on Xenograf Growth and Angiogenesis in Gastric Cancer

WANG Xiang-ming1,YU Dong-hong2,WANG Ping2,ZHANG Fan1,CAI Zhao-gen2,ZHOU Lei2,CHENG Ze-nong2(1.Department of Pathology,Yijishan Hospital,Wannan Medical College,Wuhu 241001,Anhui;2.Department of Pathology,Bengbu Medical College,Bengbu 233030,Anhui,China)  
BACKGROUND AND AIM: To investigate the effects and mechanisms of sulindac on mice xenograft,angiogenesis and biologic behaviour of gastric cancer.MATERIALS AND METHODS: Twenty athymic xeograft models with human gastric cancer cell BGC-823 were established and randomly divided into four groups,sulindac treated group(12 mg/kg),sulindac preventive group(8 mg/kg),vitamin C group(Vit C 20 mg/kg) and control group.Immunohistochemistry was used to detect the expression of COX-2,VEGF and MVD in xenografts cells.TUNEL technique was applied to examine apoptosis.RESULTS: The growth of xenografts were markedly depressed by two weeks of sulindac treatment.The xenografts volume of sulindac-treated group and sulindac-preventive group were(57.2±3.2) mm3 and(77.8±6.7) mm3,respectively significantly smaller than those of vitamin C group and control group[(120.6±12.17) mm3 and(87.7±29.0) mm3 respectively,P0.05].The xenograft volume maintained the difference until the experiment was finished.In vitamin C and control groups,the xenograft,apoptosis indexes(3.5 and 3.1,respectively) were lower than those in sulindac-treated and sulindac-preventive groups(11.6 and 10.4,respectively,P0.05).Compared with vitamin C and control groups(19.6 and 20.7),the microvessel densities were remarkedly reduced in sulindac-treated and sulindac preventive groups(5.4 and 9.0,respectively,P0.01).Compared with vitamin C and control groups,the expression of COX-2 and VEGF decreased markedly in sulindac-treated and sulindac-preventive groups(P0.05).CONCLUSION: Sulindac had obvious anti-cancer effects in vivo against gastric cancer.The mechanism ofits'anti-cancer effects may include suppressing proliferation,inducing apoptosis,and reducing angiogenesis.
【Fund】: 安徽省教育厅自然科学基金资助项目(2003kj257);; 蚌埠市科技局2003年第一批科技项目(序号10)
【CateGory Index】: R735.2
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