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Adenine-induced Chronic Renal Function Impairment in Rats

ZHAO Hai-feng1,2,ZHANG Zhao-feng1,LI Qiong1,ZHAO Ming1,LI Yong1(1.Department of Nutrition and Food Hygiene,School of Public Health,Beijing University,Beijing 100083;2.Department of Nutrition and Food Hygiene,School of Public Health,Shanxi Medical University,Taiyuan 030001,China)  
BACKGROUND AND AIM: To make rats' chronic renal function impairment model through adenine induce.MATERIALS AND METHODS: 16 male SD rats were randomly divided into control group and renal function impairment model group.Distilled water was administered orally to rats in the control group and adenine suspension 100 mg/(kg·d) was given to establish the model of renal function impairment.The experiment lasted 12 weeks.Time-dependent changes in serum creatinine(Cr),urea nitrogen(BUN) levels and creatinine clearance rate(Ccr) were monitored.Renal morphological changes were examined.RESULTS: Cr,BUN levels in the model group were higher and Ccr was lower significantly than control group.Renal function impairment was aggravated with extended experimental time.Pathological and ultramicrostructural changes were observed.CONCLUSION: Chronic renal function impairment model in rats could be successfully induced by adenine suspension.
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