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《Carcinogenesis,Teratogenesis & Mutagenesis》 2008-05
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Adenine-induced Chronic Renal Function Impairment in Rats

ZHAO Hai-feng1,2,ZHANG Zhao-feng1,LI Qiong1,ZHAO Ming1,LI Yong1(1.Department of Nutrition and Food Hygiene,School of Public Health,Beijing University,Beijing 100083;2.Department of Nutrition and Food Hygiene,School of Public Health,Shanxi Medical University,Taiyuan 030001,China)  
BACKGROUND AND AIM: To make rats' chronic renal function impairment model through adenine induce.MATERIALS AND METHODS: 16 male SD rats were randomly divided into control group and renal function impairment model group.Distilled water was administered orally to rats in the control group and adenine suspension 100 mg/(kg·d) was given to establish the model of renal function impairment.The experiment lasted 12 weeks.Time-dependent changes in serum creatinine(Cr),urea nitrogen(BUN) levels and creatinine clearance rate(Ccr) were monitored.Renal morphological changes were examined.RESULTS: Cr,BUN levels in the model group were higher and Ccr was lower significantly than control group.Renal function impairment was aggravated with extended experimental time.Pathological and ultramicrostructural changes were observed.CONCLUSION: Chronic renal function impairment model in rats could be successfully induced by adenine suspension.
【Fund】: 国家“十一·五”科技支撑项目(2006BAD27B01)
【CateGory Index】: R-332
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Chinese Journal Full-text Database 2 Hits
1 YANG Gui-mei1,HUANG Sheng-hua2,LIAN Xi-yan2,LIU Ying1,XIE Yu-huan1 (1.Kunming medical college college,Yunnan Kunming 650031,China)(2.Department of Nephrology in Second Affiliated Hospital of Kunming Medical university,Kunming 650101,China);Establishment of Hyperuricemia Model in SPF SD Rats[J];Laboratory Animal Science;2011-03
2 ZENG Ying1,ZHANG Yu1,ZHAO Ying1,LIANG Hua-min2,GUAN Xiu-wen3(1.Department of Pharmacy,Union Hospital Affiliated with the Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China;2.Department of Physiology,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China;3.Department of General Surgery,Renmin Hospital of Huanpi District,Wuhan City 430300,China);The Nephroprotective Effects of Baoshenkang Granules on Adenine-Induced Chronic Renal Failure in Rats[J];Herald of Medicine;2010-10
Chinese Journal Full-text Database 5 Hits
1 Hou Lianbing Deng Hongzhu Chen ZhiliangShi Xinghua Luo Guixiang Liao Xilin(Dept. of Clin. pharmacal of Sonth Hospital, First Military Med. Univ. Guangzhou 510515);PREARATION AND MEANINGFULNESS OF THREE KINDS OF ANIMAI MODELS OF CHRONIC RENAL FAILURE (CRF)[J];West China Journal of Pharmaceutcal Sciences;1994-03
2 LI Youyun,JIANG Zhimin,PENG Bo.Department of Nephrology,the Affiliated Luzhou Medical College,Sichuan 646000,China;Establishment of AdenineInduced Hypertensive Models of Chronic Renal Failure in Rats[J];Applied Journal of General Practice;2006-06
3 XIAO Wei, MA Yun, FU Jiangnan (Department of Chinese Traditional Medicine, the First Military Medicine University, Guangzhou 510515,China);Present Study Condition of the Methodology on CRF Animal Model[J];Chinese Journal of Laboratory Animal Science;2002-03
4 CHU Fei, ZOU Wan-zhong, SUN Suo-zhu, HAN Zhi-hui, WANG Sheng-lan. Department of Pathology, Health Science Centre of Peking University, Beijing 100083, China;Study of renal tubular epithelial cells transformations in rat tubulointerstitial fibrosis[J];Chinese Journal of Nephrology;2003-01
5 LIU Yi 1, MA Wei 2, WU Wen li 2, GUAN Jing\|huan\+1 (1 Department of Renal Internal Medicine,Wuhan Hospital No.1,Wuhan 430022; 2 Institution of Integrating of TCM with WM,Wuhan Hospital of Integrating of TCM with WM);The Levels of NO,NOS and TNF-α in Blood of CRF Rats Induced by Adenine after Treated by Jianshen Mixture[J];CHINESE JOURNAL OF EXPERIMENTAL TRADITIONAL MEDICAL FORMULAE;2000-01
Chinese Journal Full-text Database 10 Hits
1 GENG Jing(Department of Chinese Medicine,Renmin Hospital of Huaibei City,AnHui Province,Anhui Huaibei 235000,China);Clinical Observation on Chinese Medicinal Herbal Retention-enema to Treat 66 Cases of Chronic Renal Failure[J];Journal of Anhui Traditional Chinese Medical College;2006-01
2 MA Wen-bo1,GAO Xin-chun2,WANG Jian-yi1,YANG Shu-wen3 (1.Department of Urology Surgery,The Frist Hospital of Zhangjiakou,Zhangjiakou Hebei 075000;2.First Affiliated Hospital,Hebei North University,Zhangjiakou Hebei 075000;3.Second Affiliated Hospital,Hebei Medical University,Shijiazhuang Hebei 050061,China);Effect of Tiaoqi Huoxue Bushen decoction on experimental renal injury in rats[J];Journal of Bengbu Medical College;2008-04
3 WANG Guo-qiang,CHEN Wei-dong(Department of Nephrology,The First Affiliated Hospital of Bengbu Medical College,Bengbu Anhui 233004,China);The expressions of transforming growth factor-β1,thrombospondin-l and vascular endothelial growth factor in rat renal tissue in adenine-induced chronic renal failure[J];Journal of Bengbu Medical College;2010-09
4 SUN Suozhu1) CHENG Bo1) WU Xizhao1)ZHOU Yanmin1) ZOU Wanzhong 2)(1)Department of Pathology,General Hospital of the Second Artillery,PLA,100088,Beijing,China;2)Department of Pathology,Peking University Health Science Center,100083,Beijing,China);RENAL EPITHELIAL CELL APOPTOSIS,PROLIFERATION,TRANSDIFFERENTATION AND TGFβ1 EXPRESSION IN RAT URIC ACID NEPHROPATHY[J];Journal of Beijing Normal University(Natural Science);2008-03
5 ZHANG Yao-quan,FENG Bing,YUAN Fa-huan(Renal Diseases Research Center of PLA,Department of Nephrology,Xinqiao Hospital,Third Military Medical University,Chongqing 400037,China);Establishment of the rabbit model of chronic renal failure by the branchs′ deligation of arteria renalis[J];Chongqing Medicine;2008-18
6 LI Dan,ZHAO Xue-zhi~*(Department of Nephrology,Changzheng Hospital,Second Military Medical University,Shanghai 200003,China);High phosphorus foods combined with 5/6 nephrectomy for establishing rat hyperparathyroidism model secondary to chronic renal failure[J];Academic Journal of Second Military Medical University;2006-07
7 YU Jie1,ZHAO Jing-hong2,DENG Meng-yang1,HUANG Lan1(1Institute of Cardiovascular Diseases,2Renal Diseases Research Center,Xinqiao Hospital,Third Military Medical University,Chongqing 400037,China);Establishment and evaluation of uremic atherosclerosis models in ApoE~(-/-) mice[J];Acta Academiae Medicinae Militaris Tertiae;2009-19
8 LI Nuan, YANG Da-sheng (First Affiliated Hospital of Xinxiang Medical College, Henan Weihui 453100, China);The effect of Bailing capsules on experimental chronic renal failure[J];Journal of Pediatric Pharmacy;2007-02
9 GAO Hua,ZHANG Helong,CHU Xi,et al.Pediatrics Department,Zhuozhou Hospital,Hebei,Zhuozhou 072750;Protective effects of Huadu capsule on adenine-induced chronic renal failure in mice[J];Hebei Journal of Traditional Chinese Medicine;2010-07
10 ;人参养荣汤对慢性肾功能衰竭腹膜透析营养不良大鼠模型的治疗作用[J];Chinese Journal of Integrated Traditional and Western Nephrology;2000-01
China Proceedings of conference Full-text Database 1 Hits
1 ZHAO Hai-feng,ZHANG Zhao-feng,Li Qiong,ZHAO Ming,LI Yong. Department of Food and Nutritional Hygiene,School of Public Health,Beijing University,Beijing 100083,China;Marine Collagen Peptide slow down progression of chronic renal function impairment induced by adenine in rats[A];[C];2008
Chinese Journal Full-text Database 10 Hits
1 Huang Xiaowei,Mai Ciguang,Liang Bo The Affiliated Guangzhou Second People's Hospital, Guangzhou Medical College,Guangzhou 510150;The changes of serum Apo AI in patients with chronic renal diseases[J];Anhui Medical Journal;2002-05
2 LI Rui1,LIU Man-li,TIAN Xin1,MA Liang1,NAN Ya-yun1,ZHOU Da-wei1,LI Zhen2,MA Jing1(1.Department of Traditional Chinese Medicine,Xijing Hospital,the Fourth Military Medical University of Chinese PLA & the Center for Internal Medicine of Traditional Chinese Medicine of the whole Army,Shanxi Xi'an 710032,China;2.Department of Human Anatomy,Histology and Embryology,Premedical School,the Forth military Medical University,Shanxi Xi'an 710032,China);Experimental Research of Rat Model of Infertility of Kidney-yang Deficiency Induced by Different Dosage Adenine[J];Journal of Anhui Traditional Chinese Medical College;2010-02
3 XI YONG-MING,JIA LIAN-SHUN,ZHAO PENG,et al(Department of Orthopaedics,Changzheng Hospital of Shanghai,Shanghai 200003,China);THE EFFECT OF Smad PROTEIN ON OSTEOGENESIS INDUCED BY BMP-2 SIGNAL[J];Acta Academiae Medicinae Qingdao Universitatis;2007-06
4 ZHANG Lei1,LIU Xu-sheng2,YANG Ni-zhi2,JIN Hua1,DUAN Xiao-jun1(1The Second Clinical Medical College of Guangzhou University of Chinese Medicine,Guangzhou 510405,China; 2The Key Discipline of Nephropathy,Guangdong Provincial Hospital of Chinese Medicine,Guangzhou 510120,China);Analysis on application of characteristic treatment of TCM for chronic renal failure[J];China Journal of Traditional Chinese Medicine and Pharmacy;2010-06
5 Jiang Shujun 1,Wang Guilan 1,Xu Lanzhi 2 (1 Binzhou Medical College,Binzhou 256603;2 Weifang Medical College);EFFECTS OF GLUCOCORTICOID AND EPIMEDIUM ON HYPOTHALAMUS-PITUITARY-ADRENOCORTEX AXIS[J];Journal of Binzhou Medical College;2004-02
6 Feng Xuemei, Zheng Jun, Wang Miqu et al Chengdu University of TCM (Chengdu,610075,China);The Content Variation of Middle Molecules Substances and Hydrosulfide Group in Plasma of "Terror Leading to Disorder of Kidney" Mice Moddle[J];JOURNAL OF CHENGDU UNVERSITY OF TARDITIONAL CHINESE MEDICINE;1997-03
7 Qin Luping, Shi Hanping, Wang Hongbin, Zheng Shuiqing, Zhang Jiaqing(Department of Pharmacognosy, College of Pharmacy, Second Military Medical University, Shanghai, 200433);Effects of Cnidium monnieri coumarins on the grade of learning and memory and neuropeptides in Kidney Yang deficiency rats[J];ACADEMIC JOURNAL OF SECOND MILITARY MEDICAL UNIVERSITY;1997-02
8 Liu Hong1,Liu Qing1,Lei Han2,Li Xiulan1,Chen Xian1 (1Department of Clinical Research Center,2Department of Cardiology,First Affiliated Hospital,Chongqing Medical University,Chongqing,400016,China);Inflammatory stress promotes lipid accumulation in aorta of scavenger double knockout mice[J];Acta Academiae Medicinae Militaris Tertiae;2010-16
9 WANG Hui1, CHEN Qing-Jiang2, YANG Zai-Gang3, ZHANG Bing4, MIAO Ming-San51Department of Chinese Materia Medica, 5Pharmacy College, Henan University of Traditional Chinese Medicine, Zhengzhou 450008, China, 2Department of Nephrology, 3Department of Endocrinopathy, First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China, 4Pharmacy College, Beijing University of Traditional Chinese Medicine, Beijing 100102, China;Effects of Leonurs Heterophyllus Sweet on blood rheology and transforming growth factor-β_1 in rats with diabetic nephropathy[J];Journal of the Fourth Military Medical University;2007-16
10 LI Qing yang,ZHEN Jia keng(Dept.of Traditional Chinese Medicine,FCTCM,Fuzhou, Fujian 350003,China);Study on Relationship Between Senile Deficiency of Kidney and T-lymphocyte Subsets[J];Journal of Fujian College of Traditional Chinese Medicine;2001-02
【Secondary References】
Chinese Journal Full-text Database 3 Hits
1 Yang Huijun1 Li Zhaofu2 Peng Jiangyun2 Yunnan College of Traditional Chinese Medicine,Kunming Yunnan China 650500 The First Affiliated Hospital of Yunnan College of Traditional Chinese Medicine,Kunming Yunnan China 650021;Overview Research of Hyperuricemia Animal Model[J];China Journal of Chinese Medicine;2013-01
2 WANG Ying-ping①,WANG Yan-xia②,LIANG Zhu②,YU Yan-li② ①College of Pharmacy,Shandong University of TCM,Jinan 250355,China; ②Department of Pharmacy,General Hospital of Jinan Military Command,Jinan 250031,China;Effect of Xiaodan Granules on Chronic Renal Failure Caused by Adenine in Rats[J];Pharmaceutical Journal of Chinese People's Liberation Army;2013-03
3 CHEN Guang-liang,ZHU Li-ran,NA Sha,LI Li(Integrative Medicine College,Anhui University of Traditional Chinese Medicine,Hefei 230038,China);Effect of total saponin of Dioscorea on chronic hyperuricemia and expression of URAT1 in rats[J];China Journal of Chinese Materia Medica;2013-14
【Secondary Citations】
Chinese Journal Full-text Database 9 Hits
1 XU Yan, ZHAO Zhenxiao, ZHAO Xiuzhen \ Department of Nephrology, The Affiliated Hospital of Qingdao University Medical College, Qingdao 266003;A CLINICAL OBSERVATION OF INSULIN RESISTANCE IN PATIENTS WITH HYPERTENSIVE NEPHROSCLEROSIS AND RENAL HYPERTENSION[J];Acta Acadimae Medicinae Qingdao;2001-04
2 Yuan Fahuan , Liao Lisheng (Department of Nephrology, Xinqiao Hospital, Third Military Medical College, Chongqing, 630037);Establishment and evaluation of the cadmium-induced mouse model of chronic renal failure[J];Acta Academiae Medicinae Militaris Tertiae;1993-06
3 FU Xiao qing\+1,WU Yi man\+2,CHEN Zhen bin\+3,et al\;(1.Dept.of Traditional Chinese Medicine,FCTCM,Fuzhou,Fujian 350003,China;\;2.Dept.of Modern Medicine,FCTCM,Fuzhou,Fujian 350003,China;\;3.Lab of Electron Microscopy of Fujian Medical University,Fuzho;Study on Adenine-modeled Kidney-YANG-deficiency Syndrome of Chronic Renal Failure by Pathological Method and Electron Microscopy in Rats[J];Journal of Fujian College of Traditional Chinese Medicine;2002-03
4 Wang Yaoguang The Second Affiliated Hospital of Tianjing College of TCM(300150);A Primary Approach to the Nature of Blood Stasis of Animal Model with Chronic Renal Failure Caused by Electric Cauterization[J];HENAN TRADITIONAL CHINESE MEDICINE;1997-01
5 Zhou Xiaozhou ;Zhang Shengguang; Yang Xiao; Wei Yi (Hunan College of TCM, Changsha, China410007);Study on Mechanism of Adenine-Induced Chronic Renal Failure in Rat[J];BASIC MEDICAL SCIENCES AND CLINICS;1997-01
6 Lin Na, Chen Ronghua, Huang Songming, et al. Center of Pediatric Nephrology, Nanjing Medical University, Nanjing 210029;Modified Animal Model of Rapid Glomerulosclerosis[J];ACTA ACADEMIAE MEDICINAE NANJING;2000-03
7 Wang Wei,Wang Qingzhou,Chen Xueyan et al(National Institute for the Control of Pharmaceutical and Biological Products,Beijing 100050);Establishment of Rat Model of Chronic Renal Failure Caused by Adenine[J];CHINESE JOURNAL OF BIOLOGICALS;1999-02
8 XIONG Zu Ying, MEI Qiao, DING Chang Hai, XU Shu Yun (Dept of Nephrology, The First Hospital of Anhui Medical University Insititute of Clinical Pharmacology, Anhui Medical University, Hefei 230032);A model of adriamycin induced nephropathy after pinealectomy[J];CHINESE PHARMACOLOGICAL BULLETIN;1999-03
9 Deng Hongzhu,Jin Weijun,Hou Lianbing and Liao Xilin(Nanfang Hospital,First Military Medical University,Guangzhou 510515);Methodology of Pharmacodynamic Study on Chronic Renal Failure[J];CHINA JOURNAL OF CHINESE MATERIA MEDICA;1998-04
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