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《Carcinogenesis,Teratogenesis & Mutagenesis》 2009-01
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Acute Toxicity and the Genotoxicity of Alfalfa Total Saponins

LI Guo-feng,LI Lan-fang,ZHANG Qin-zeng,HAO Na,WANG Wei(Hebei Center for Disease Control and Prevention,Shijiazhuang 050021,China)  
BACKGROUND AND AIM:To observe the acute toxicity and the genotoxicity of alfalfa total saponins(ATS).MATERIALS AND METHODS:Kunming mice were used to test the LD50 of ATS.The mouse bone marrow micronucleus test and the mouse sperm morphology test were used to evaluate genotoxicity of ATS.RESULTS:The LD50 of ATS was 13.01 g/kg,95% confidence interval was 12.46~13.58 g/kg.The micronucleus rates and sperm abnormality rates were negative.CONCLUSION:The ATS was considered a substance with no toxicity and genotoxicity in this study.
【Fund】: 河北省科学技术研究与发展计划项目(04276101D-51)
【CateGory Index】: R114
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