Full-Text Search：
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Carcinogenesis,Teratogenesis & Mutagenesis》 2009-02
Add to Favorite Get Latest Update

Inhibitory Effects of c9,t11-conjugated Linoleic Acid on Matrix Metalloproteinase of SGC-7901 Cell Line via COX-2 Pathway

ZHANG Jing-shu1,CHEN Bing-qing2,YANG Yan-mei3,SUN Wen-guang2(1.Department of Toxicology,Tianjin Center for Disease Control and Prevention,Tianjin 300011;2.Department of Nutrition and Food Hygiene,Public Health College,Harbin Medical University,Harbin 150086;3.The Tumor Hospital for Harbin Medical University,Harbin 150081,China)  
BACKGROUND AND AIM:To study the inhibitory effects of c9,t11-conjugated linoleic acid(c9,t11-CLA)on matrix metalloproteinase of human gastric carcinoma cell line(SGC-7901)via cyclooxygenase-2 pathway.MATERIALS AND METHODS:Inhibiting COX-2 activity by 100 μmol/L COX-2 inhibitor NS-398 in SGC-7901 cells,which were then treated with c9,t11-CLA by 200,100,50,25 μmol/L for 24 h.The expressions of MMP-2,MMP-9 mRNA were measured by RT-PCR.RESULTS:At the concentrations of 200,100,50,25 μmol/L,c9,t11-CLA decreased the expressions of MMP-2,MMP-9 mRNA.But when the SGC-7901 cells were treated with NS-398 in advance,MMP-2 and MMP-9 mRNA level were not decreased in any concentration of c9,t11-CLA groups.CONCLUSION:c9,t11-CLA could inhibit the expressions of MMP-2,MMP-9 mRNA in SGC-7901 cells,and COX-2 might play an important role in mediating the ability of c9,t11-CLA to inhibit the matrix metalloproteinase of tumor cells.
【Key Words】： conjugated linoleic acid cyclooxygenase-2 matrix metalloproteinase
【Fund】： 国家自然科学基金资助项目(30271129)
【CateGory Index】： R735.2
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【Citations】
Chinese Journal Full-text Database 3 Hits
1 Xue Yingben,Chen Bingqing,Zheng Yumei, Yuan Lili,et al. The Public Health School of Harbin Medical University,Harbin 150001,China;Effects of conjugated linoleic acid on the metastasis of mouse melanoma B16-MB[J];Journal of Hygiene Research;2001-01
2 YANG Yan mei *,CHEN Bing qing,ZHENG Yu mei,WANG Xuan lin,LIU Jia ren,XUE Ying ben,LIU Rui hai * Department of Nutrition and Food Hygiene,Public Health School of Harbin Medical University,Harbin 150001,China;The effects of conjugated linoleic acid on the expression of invasiveness and metastasis-associated gene of human gastric carcinoma cell line[J];Chinese Journal of Preventive Medicine;2003-01
3 ZHANG Jing-shu, CHEN Bing-qing, GAO Yan-hui,YANG Yan-mei,WANG Xuan-lin,SONG Yang,SUN Wen-guang . Department of Nutrition and Food Hygiene, Public Health School of Harbin Medical University, Harbin 150001, China;Effects of conjugated linoleic acid on the expression of critical enzymes of linoleic acid metabolism in tumor cell[J];Chinese Journal of Preventive Medicine;2005-03
【Co-citations】
Chinese Journal Full-text Database 9 Hits
1 LI Chun, LIU Li-bo, ZHANG Lan-wei Northeast Agriculture University, Harbin 150030, China;Physiological Function and Application of Conjugated Linoleic Acid[J];Journal of Cereals & Oils;2004-07
2 Liu Xiaohua Cao Yusheng Chen Yan (The Key Laboratory of Food Science of MOE, Nanchang University, Nanchang, 330047);Studies on the Production of Conjugated Linoleic Acid by Microbe[J];Food and Fermentation Industries;2003-09
3 ZHANG Ya-gang, WEN Bin, ELI Wumanjiang(Graduate School of Chinese Academy of Sciences, Beijing 100039, China; Xinjiang Institute of Physical and Chemical Technology, The Chinese Academy of Sciences, Urumqi 830011, Xinjiang, China );Mechanism for Bio-activity of Conjugated Linoleic Acid[J];Life Science Research;2002-S1
4 DONG Gui-cheng1,2,CAO Li-xia1,NA Risu1,ZHAO Rigetu1,LI Shao-ying2,BO Gerileitu1,* (1.College of Life Science, Inner Mongolia University, Huhhot 010021, China; 2.College of Food Science and Enginzeering, Inner Mongolia Agricultural University, Huhhot 010018, China);Inquire Conjugated Linoleic Acid Anti-carcinogenesis Effects and Mechanisms[J];Food Science;2008-04
5 Zhang Yagang 1,2 Wumanjiang Eli 1 YAN Dayu 2 Wen Bin 1 1.(Xinjiang Institute of Physical and Chemical Technology,The Chinese Academy of Sciences,Urumqi,830011) 2.(Graduate School of the Chinese Academy of Sciences,Beijing,100039 );Energy Mechanism for Bio-activity of Conjugated Linoleic Acid and Energy Drug[J];Journal of Xingjiang Normal University(Natural Sciences Edition);2003-01
6 FENG You-sheng (Library,Chongqing Technolong and Business University,Chongqing 400067,China);Physiological functions of conjugated linoleic acid[J];Journal of Chongqing Technology and Business University(Natural Science Edition);2007-04
7 YANG Yan-mei,CHEN Bing-qing,WANG Xuan-lin,et al.Department of Nutrition and Food Hygiene,Public Health School of Harbin Medic al University(Harbin 150001,China);Effects of conjugated linoleic acid on invasion of human gastric carcinoma cell in vitro[J];China Public Health;2003-10
8 Yang Yanmei, Chen Bingqing, Xue Yingben,Zheng Yumei, et al. Public Health School of Harbin Medical University, Harbin 150001, China;Effects of c9,t11-conjugated linoleic acid on the metastasis of human gastric carcinoma cell line[J];Journal of Hygiene Research;2003-02
9 ZHANG Jing-shu WANG Qi CHEN Bing-qing YANG Yan-mei GAO Yan-hui SUN Wen-guang Department of Toxicology,Tianjin Centers For Disease Control And Prevention,Tianjin 300011,China;Study on inhibitory effects of c9,t11-conjugated linoleic acid on migration of human gastric carcinoma cell line via cyclooxygenase-2 pathway[J];Chinese Journal of Preventive Medicine;2007-06
China Proceedings of conference Full-text Database 1 Hits
1 Zhang Jingshu1 Wang Chunhua1 Chen Bingqing2 Yang Yanmei2 Gao Yanhui2 Sun Wenguang2 (1.Department of Toxicology, Tianjin Centers For Disease Control And Prevention , Tianjin 300011, China;2.Department of Nutrition and Food Hygiene, Public Health College, Harbin Medical University, Harbin, 150086 , China);Study on inhibitory effects of c9,t11-conjugated linoleic acid on matrix metalloproteinase of human gastric carcinoma cell line(SGC-7901) via cyclooxygenase-2 pathway[A];[C];2008
【Secondary Citations】
Chinese Journal Full-text Database 4 Hits
1 Zhu Wei-yong,Fang Wei-gang,Zheng Jie,et al Department of Pathology, Beijing Medical University, Beijing 100083;EFFECTS OF RETINOIC ACID ON THE ADHESION AND MOTILITY OF METASTATIC HUMAN LUNG CANCER CELL SUBLINE (PGCL3)[J];CHINESE JOURNAL OF ONCOLOGY;1994-05
2 Han Li-qun,Gao Jin,DOngHua-yi,et al Department of Pathology, Institute of Basic Medical Sciences,Chinese Academy of Medical Sciences, Beijing 100005;STUDIES ON THE GAP JUNCTIONAL INTERCELLULAR COMMUNICATION OF HUMAN NASOPHARYNGEAL CARCINOMA CELLS AND EFFECT OF RⅡ[J];CHINESE JOURNAL OF ONCOLOGY;1994-05
3 XUE Yingben,CHEN Bingqing,LIU Jiaren,et al Department of Nutrition and Food Hygiene,School of Public Health,Harbin Medical University,Harbin 150001,China;The inhibition of mouse forestomach neoplasm induced by B(a)P through MAPKs pathway by conjugated linoleic acid[J];Chinese Journal of Preventive Medicine;2001-03
4 LIU Jiaren, CHEN Bingqing,XUE Yingben,et al Department of Nutrition and Food Hygiene,School of Public Health, Harbin Medical University,Harbin 150001,China;Conjugated linoleic acid inhibits the growth of mammary carcinoma cells[J];Chinese Journal of Preventive Medicine;2001-04
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved