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《Carcinogenesis,Teratogenesis & Mutagenesis》 2009-04
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Impact of Benzo(a) pyrene on DNA Damage and Antioxidative Activities in Liver of Sebastiscus Marmoratus

WANG Yun1,WANG Shun-chang1,LU Jian-feng2(1.Department of Life Sciences,Huainan Normal University,Huainan 232001,Anhui;2.The School of Biotechnology and Food Engineering,Hefei University of Technology,Hefei 230009,Anhui,China)  
BACKGROUND AND AIM: This study was designed to investigate antioxidative activities and DNA damage to determine toxicological effects of benzo(a)pyrene(BaP) on liver of Sebastiscus marmoratus.MATERIALS AND METHODS: Sebastiscus marmoratus were exposed through a water column to Bap(10,100,1 000 ng/L) and sampled at 0 d,7 d,25 d,50 d after exposure and 7 d,20 d after recovery.Activities of superoxide dismutase(SOD),glutathione S-transferase(GST),reduced glutathione(GSH) content and DNA single strand breaks were detected.RESULTS: Total SOD activity was inhibited after 7 d of exposure,while it was induced after 25 d and 50 d of exposure.GSH content and GST activity were mainly induced.DNA damage was accentuated by longer exposure period and higher exposure concentration.CONCLUSION: Combination of SOD,GST activities and GSH content or detection of DNA single strand breaks in liver of Sebastiscus marmoratus can serve as potential biomarkers to monitor marine pollution of polycyclic aromatic hydrocarbons(PAHs).
【Fund】: 安徽省高校省级自然科学研究项目(NO.KJ2008B200)
【CateGory Index】: X174
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