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《Carcinogenesis,Teratogenesis & Mutagenesis》 2009-06
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Genotoxicity of Bezoar Antidotal Tablets

DONG Ju1,TANG Meng2,WANG Shu2(1.Institute of Basic Medical Science,Nanjing University of Traditional Chinese Medicine,Nanjing 210046;2.School of Public Health,Southeast University,Nanjing 210009,China)  
BACKGROUND AND AIM: To evaluate the genotoxicity of bezoar antidotal tablets.MATERIALS AND METHODS: The Ames test,the mouse micronucleus test and the mouse sperm abnormality test were used to evaluate the genotoxicities of bezoar antidotal tablet.RESULTS: In the Ames test,the number of revertants in all dose groups was less than twice that of solvent control group.In the mouse micronucleus test and sperm abnormality test,no significant differences were observed in the three dose groups compared with that of control group.CONCLUSION: Under this experimental condition,no genotoxic effects had been found in bezoar antidotal tablets.
【Fund】: 南京中医药大学青年科技基金资助项目(07XZRO2)
【CateGory Index】: R285.5
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