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《Carcinogenesis,Teratogenesis & Mutagenesis》 2010-03
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Effects of fructus schisandrae chinensis decoction on embryo-fetal development in rats

ZHANG Min,LIU Xiao-meng,SONG Jie,HU Yan-ping,WANG Xiu-wen,LI Bo(National Institute for the Control of Pharmaceutical and Biological Products,National Center for Safety Evaluation of Drugs,Beijing 100176,China)  
OBJECTIVE:The effects of fructus schisandrae chinensis decoction on dams and embryo-fetal development were examined using Sprague-Dawley rats.METHODS:Fructus schisandrae chinensis decoction was administered at dose of 15 g/kg(herbal raw material)per day orally to groups consisting of 20 mated animals,once daily for 12 days from day 6 through day 17 of gestation.The clinical signs of rats,as well as abortions,premature deliveries,body weights,and feed intake,were monitored.Caesarean section and autopsy were performed on GD 20.Uterine content were evaluated for number and distribution of implantations,live and dead fetuses.The number of corpora lutea in each ovary was also recorded.Fetuses were weighed and examined for gender and appearance,visceral and skeletal alterations.RESULTS:There were no significant differences in any parameter of dams and fetuses.CONCLUSION:No maternal toxicity and embryo-fetal toxicity were found when fructus schisandrae chinensis decoction administered orally during the period from implantation to closure of the hard palate.
【Fund】: 国际科技合作项目(2006DFB31690):促进中药材在法国的注册和进入
【CateGory Index】: R285.5
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【Citations】
Chinese Journal Full-text Database 2 Hits
1 HU Yan-ping,WANG Xin,SONG Jie,ZHANG Min,WANG Xiu-wen,LI Bo(National Center for Safety Evaluation of Drugs,National Institute for the Control of Pharmaceutical and Biological Products,Beijing 100176,China);Genotoxicity of Fructus Schisandrae Chinensis Concoction[J];Carcinogenesis,Teratogenesis & Mutagenesis;2009-04
2 HE Lai-ying,FENG Xiao-lian,SUN Ming,et al.(National Institute of Nutrition and Food Safety,China CDC,Beijing 100021);A Study of Acute and Genetic Toxicity of the Crude Extract from Schisandra Chinensis[J];Practical Preventive Medicine;2004-04
【Secondary Citations】
Chinese Journal Full-text Database 7 Hits
1 XIE Ming(Supervision and Test Center f or Pesticide Safety Evaluation and Qualit y Control & Nation Research Center for New Drug Safty Evalution,Shen yang 110021,China);THE MOUSE LYMPHOMA CELL MUTATION ASSAY[J];Carcinogenesis,Teratogenesis and Mutagenesis;2003-03
2 Department of Pharmarcognosy Qi Zhi, et al;EFFECTS OF THE VOLATHE OIL FROM FRYUTS SCHISANDRA CHINFENSIS ON THE CENTRAL NERVOUS SYSTEM[J];;1988-06
3 XIONG Yan-bin, ZHANG Rui-fang, HUANG Xing-xing.Department of Stomatology, Xianning Medical College. Xianning 437100 [;The Experimental Study and Clinically Therapentic Effect Detection of SCE on Anti-Cariogenicity.[J];Journal of Comprehensive Stomatology;2000-04
4 SUEN KAAN(Department of fo Pharmacology,Anshan Mcdical Mekical College,Inshan);THE ACTION OF SCHIZANDRA CHINENSIS ON RESPIRATION AND BLOOD PRESSURE IN LABORATORY ANIMALS[J];Acta Pharmaceutica Sinica;1959-07
5 NIU Xin-yi, WANG Wei-jun, BIAN Zhen-jia and REN Zhi-hong (Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing);EFFECTS OF SCHIZANDROL A ON THE CENTRAL NERVOUS SYSTEM[J];Acta Pharmaceutica Sinica;1983-06
6 WANG Yan 1,WANG Jin fu 1,YOU Hong 2,CUI Yu hong 2 (1.Applied Chemistry Department,2.Science and Environmental Engineering Department,Harbin Institute of Technology,Harbin 150001,China);The analysis of the essential oil from the seeds of chisandra chinensis by GC MS[J];Chinese Pharmaceutical Journal;2001-02
7 Wang Ke, Song Wanzi and Tong Yuyi (Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050);Studies on the Identification of Schisardra by TLC-Densitometry[J];China Journal of Chinese Materia Medica;1991-02
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