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《Carcinogenesis,Teratogenesis & Mutagenesis》 2010-04
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The immunoregulatory activity of cortex periplocae extract on the mice lymphocyts

LI Jun-xin1,JIANG Yu-hong1,SHAN Bao-en2(1.Women and Children's Medical Center,Qingdao 266011,Shandong;2.Science and Research Center,The Fourth Hospital of Hebei Medical University,Shijiazhuang 050011,Hebei,China)  
OBJECTIVE:Study on the immunoregulatory function of cortex periplocae extract(CPE)on mice lymphocytes.METHODS:We separated mice lymphocytes with aseptic manipulation and cultivated them with CPE(concentrations were 250,125,64,32,16,8 μg/ml),Then the effect of CPE on the proliferative activity of mice lymphocytes induced by ConA was measured by using MTT method.The activity of NK cells was assayed by a released LDH assay.The content of tumor necrosis factor-α(TNF-α)was evaluated by biological method.RESULTS:CPE within the range of 8 to 64 μg/ml could markedly stimulate the mice lymphocyte to proliferate and enhance the activity of NK cells.It stimulated monocytes to produce TNF-α as well.CONCLUSION:CPE showed immunoregulatory activity on mice lymphocytes.This could be used clinically for modulating immune response or for treating tumors and other diseases.
【Fund】: 国家自然科学基金项目(30371753);; 河北省自然科学基金项目(C2004000610)
【CateGory Index】: R285.5
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