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《Carcinogenesis,Teratogenesis & Mutagenesis》 2010-05
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Oxidative damage which caused by γ-rays promotes aging

LIANG Xin,LI Wen-Li,HAI Chun-xu,YANG Xue-kang,ZHANG Wei,BAI Hua.(Department of Toxicology,the Fourth Military Medical University,Xi'an 710033,Shanxi,China)  
OBJECTIVE:To assess the relation of aging and oxidative damage caused by γ-rays. METHODS: 60 mice were divided into 4 groups:group A was control group; mice of group B were treated with intraperitoned D-galactose; mice of group C were irradiated by γ-rays; mice of group D were treated with D-galactose and irradiation. The activity of SOD,contents of MDA and lipofuscin and AGEs in blood serum were determined,the expression in of β-galactosidase by staining was measured at the end of 80 days' experiment. RESULTS: Compared with group A,the activity of SOD was decreased in group B(P0.05),the level of AGEs and contents of MDA and lipofuscin increased in group B(P0.05),also the β-galactosidase activity was positive. The activity of SOD was decreased in group C(P0.05),contents of MDA and lipofuscin increased in group C(P0.05),also the β-galactosidase activity was positive,but no significant difference was found in the level of AGEs in group C(P0.05). Compared with group B,the activity of SOD was decreased in group D(P0.05),the level of AGEs and contents of MDA and lipofuscin were increased in group D(P0.05),also the β-galactosidase activity was raised. CONCLUSION:Aging was enhanced by oxidative damage caused by γ-rays.
【CateGory Index】: R363
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