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《Carcinogenesis,Teratogenesis & Mutagenesis》 2011-01
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Combined effects of vitamin E andβ-carotene on radiation injuries in mice

ZHENG Yi-lin~1,LIANG Xin~(2,*),HAI Chun-xu~2, CHEN Hong-li~2,LIU Rui~2,QIN Xu-jun~2 (1.Department of Stomatology,the Fourth Military Medical University;2.Department of Toxicology,Faculty of Preventive Medicine,the Fourth Military Medical University, Xi'an 710032,China)  
OBJECTIVE:To study the antioxidation of vitamin E and/orβ—carotene on mice induced by radiation.METHODS:Mice were divided randomly into 5 groups of normal control,positive,vitamin E,β-carotene, vitamin E plusβ-carotene.All of the animals except the normal control were irradiated with 4.5 Gy of ~(60)Coγ.After the radiation,the vitamin supplementation animals were given vitamin E[30 mg/(kg·d)]and/orβ—carotene[20 mg/(kg·d)]. Three days later,the animals were sacrificed.The retinol binding protein(RBP) in serum was analyzed with enzyme-linked immunosorbent assay(ELISA),and the levels of malondialdehyde(MDA) and reduced glutathione(GSH) in serum and liver were determined with fluorometry.RESULTS:~(60)Coγradiation decreased the level of RBP in serum.Supplementation of vitamin E and/orβ-carotene showed certain protection.Vitamin E and/orβ-carotene also inhibited the increase of MDA and the decrease of GSH in serum and liver induced by ~(60)Coγradiation.Vitamin E alone showed the best protection. CONCLUSION:Both vitamin E andβ-carotene showed protective effects on the oxidative injuries in mice induced by radiation.But the combined use of vitamin E andβ-Carotene showed antagonistic rather than synergistic effect.
【Fund】: 本科生课外科研课题
【CateGory Index】: R151.4
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