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《Carcinogenesis,Teratogenesis & Mutagenesis》 2011-04
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Effect of Duyiwei capsule on proliferating cell nuclear antigen expression in rats

WANG Lan~1,ZHANG Yong-dong~1,LIANG Tao~1, LUO Yan~1,GUO Hong-yun~1,ZHANG Xiao-wen~(2,*) (1.Department of Pharmacology and Toxicology,Gansu Province Academy of Medical Sciences,Lanzhou 730050,Gansu;2. Guangzhou Institute of Sports Science,Guangzhou 510650, Guangdong,China)  
OBJECTIVE:To investigate the effect of Duyiwei(lamiophlomis rotate) capsule on the expression of proliferating cell nuclear antigen(PCNA) in Wistar rats.METHODS:40 Wistar rats,half male half female,were randomly divided into 5 groups:model group,PTCA group,Duyiwei(Lamiophlomis rotate) capsule 0.50,1.25,2.50 g/kg,positive control group(salvia miltrorrhiza tablet 1.0 g/kg).Oral administration of drugs was performed in each group,continuously 5 days.Then all rats were treated by percutaneous transluminal coronary angioplasty(PTCA) for the establishment of carotid balloon injury model.Then drug treatment continued after PTCA for 28 days.Carotid artery segment underwent routine biopsy immunohistochemistry and PCNA expression determination.RESULTS:In the normal artery,these was low level or no expression of PCNA.In the arterial intima of the model groups,33.71%was PCNA-positivewith each dose of Duyiwei capsule group showing significant differences(P0.05).CONCLUSION:Duyiwei capsule significantly inhibited the expression of PCNA,which may be one of its mechanisms in preventing restenosis after carotid artery injury in rats.
【Fund】: 甘肃省医学科学研究院科研基金课题(200709)
【CateGory Index】: R285.5
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