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《Carcinogenesis,Teratogenesis & Mutagenesis》 2011-05
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Genetic toxicity of recombinant human lactoferrin

LIU Shan,FENG Xiao-lian,LI Chen-xi,GENG Gui-ying, LIU Hai-bo,ZHI Yuan,XU Hai-bin~* (Institute for Nutrition and Food Safety,China Center for Disease Control and Prevention,Beijing 100021,China)  
OBJECTIVE:To evaluate genetic toxicity of recombinant human lactoferrin(rhLf) expressed in milk from genetically modified cow.METHODS:In Ames test,TA97,TA98,TA100,and TA102 strains were treated with 62,185,556,1 667 and 5 000μg recombinant human lactoferrin(rhLf) per plate.In mice bone marrow cell micronucleus test and mice sperm abnormality test,1.88,3.75 and 7.50 g/kg rhLf groups and control groups were set.RESULTS:Back mutation colonies of rhLf groups did not exceed more than twice that of the control in Ames test and there was no dose-response relationship.In mice bone marrow cell micronucleus test,no significant difference was found in PCE/RBC and micronucleus rate between rhLf-treated groups and negative control group.In mice sperm abnormality test,sperm abnormality rate of rhLf-treated groups was lower than that of negative control.CONCLUSION:No genetic toxicity was observed in recombinant human lactoferrin in this study.
【Fund】: 国家高技术研究发展计划(863计划)项目(2007AA100506);; 转基因生物新品种培育科技重大专项(2008ZX08011-005)
【CateGory Index】: R114
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