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《Carcinogenesis,Teratogenesis & Mutagenesis》 2012-04
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Genotoxicity of di-phenyl-di-(2,4-chlorobenzohydroxamato) tin

QIN Xiu-jun~1,YUE Juan~1,LI Shu-fang~1, YIN Jing-jing~1,XU Wen-li~1,ZHENG Juan~2, LI Yun-lan~2,LI Qing-shan~(2,*) (1.China Institute for Radiation Protection,Taiyuan 030006; 2.School of Pharmaceutical Science,Shanxi Medical University, Taiyuan 030001,Shanxi,China)  
OBJECTIVE:To investigate the genotoxicity of di-phenyl-di-(2,4- chlorobenzohydroxamato) tin(DPDCT).METHODS:Ames test,chromosomal aberration test in Chinese hamster lung(CHL) cell and micronucleus test in mouse bone marrow were carried out.RESULTS:In Ames test,at concentration of 500 and 5 000μg/plate,the reversal colonies in TA97(±S9),TA98(±S9),TA100(±S9) and TA1535(+S9) were significantly increased(P 0.01) compared with negative control.At concentration of 4.00μg/ml,DPDCT induced a significant increase in number of chromosomal aberrations(P 0.01) compared with solvent control at 24 h after administration without metabolic activation. Micronucleus test indicated DPDCT had no mutation effect on the rate of mouse micronucleated polychromatic erythrocytes at dose of 12.5-50.0 mg/kg.CONCLUSION:DPDCT showed genotoxicity in vitro,but not in vivo.
【Fund】: 国家“重大新药创制”科技重大专项(2009ZX09103-104)
【CateGory Index】: R114
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