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《Carcinogenesis,Teratogenesis & Mutagenesis》 2013-04
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Positive modeling study on fertility and early embryo developmental toxicity in SD male rat

ZHOU Li,WANG Yong,WANG Rong,XU Li, LUO Yong-wei,WANG Hua,SUN Zu-yue* (Department of Pharmacology and Toxicology, Shanghai Institute of Planned Parenthood Research, National Evaluation Center for the Toxicology of Fertility Regulation Drugs, Shanghai 200032, China)  
OBJECTIVE: To establish male rat fertility and early embryo developmental toxicity test (I section) positive control model,cyclophosphamide was given by i.p. before mating. METHODS:Male Sprague-Dawley rats were divided into control group,cyclophosphamide I and cyclophosphamide II groups. Cyclophosphamide groups were given intraperitoneally on day 1 of 9 weeks (100 mg/kg) and the first 5 days of 9 weeks (20 mg/kg). Male rats were sacrificed after mating,the parameters were observed and tested.RESULTS:Positive groups male animals showed reversible depilatory. Animal body weight and then food consumption were decreased significantly when compared with the control group,although no significant differences in the hormone level were found.Weights of auxiliary reproductive organ were significantly decreased,time for penis erection was significantly longer,sperm count and sperm activity ratio were decreased,and sperm malformation rate was increased significantly. CONCLUSION:Cyclophosphamide exeited significant effects on male fertility,and both treatment methods could be used to establish positive fertility and early embryo developmental toxicity test model.
【Fund】: 十二五“重大新药创制”科技重大专项(2011ZX09301-005);; 上海市实验动物创新行动计划项目(11140901300和11140901303);; 上海市人才发展基金(2010031)
【CateGory Index】: R114
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