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《CARCINOGENESIS, TERATOGENESIS AND MUTAGENESIS》 1995-03
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STUDY ON THE MUTAGENIC AND ANTIMUTAGENIC POTEN-TIALS OF GYPENOSIDES(GPS)IN MICE

Du Yangyang and Mo ZiyaoGuangzhou Anti-epidemic Station,Guangzhou 5l0080  
The result showed that acute toxicity of GPS is over l0000mg/kg and has no mutagenic potentialin the mutation assays. White animals were administrated GPS,the micronucleus rate of PEC in mice bonemarrow induced by cyclophosphamide(CP)were obviously inhibited.1000mg/kg 11.9‰,2500mg/kg 8.5‰,500Omg/kg 13.6‰ compared to CP 29. 9‰(P0.05)。From 5-50mg/plate.GPS were also inhibited the re-version frequencies in strain TA98,TA100 and TA102 by varied positive mutagens.GPS showed a good dose~respose inhibition of revere mutation of strain TA98 induced by 2-AF(S9+).The results suggested thatGPS have a possible antimugenesis in both vitro and vivo.The probable mechanism of antimutagenesis of GPShas been suspected.
【CateGory Index】: R961
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