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《CARCINOGENESIS, TERATOGENESIS AND MUTAGENESIS》 1995-03
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STUDY ON THE MUTAGENIC AND ANTIMUTAGENIC POTEN-TIALS OF GYPENOSIDES(GPS)IN MICE

Du Yangyang and Mo ZiyaoGuangzhou Anti-epidemic Station,Guangzhou 5l0080  
The result showed that acute toxicity of GPS is over l0000mg/kg and has no mutagenic potentialin the mutation assays. White animals were administrated GPS,the micronucleus rate of PEC in mice bonemarrow induced by cyclophosphamide(CP)were obviously inhibited.1000mg/kg 11.9‰,2500mg/kg 8.5‰,500Omg/kg 13.6‰ compared to CP 29. 9‰(P0.05)。From 5-50mg/plate.GPS were also inhibited the re-version frequencies in strain TA98,TA100 and TA102 by varied positive mutagens.GPS showed a good dose~respose inhibition of revere mutation of strain TA98 induced by 2-AF(S9+).The results suggested thatGPS have a possible antimugenesis in both vitro and vivo.The probable mechanism of antimutagenesis of GPShas been suspected.
【CateGory Index】: R961
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【Co-references】
Chinese Journal Full-text Database 10 Hits
1 Wang Tingxin, Qin Shuzheng, Zhao wen, Jiang Dongsheng, Ma Xiaotong, Bian Qiangrong HeBei Sanitary Epidemic Station, Baoding\ 071000;INHIBITORY EFFECT OF LAMINARIA JAPONICA POLYSACCHARIDES ON MICRONUCLEUS RATE INDUCED BY CYCLOPHOSPHAMIDE IN MICE[J];CARCINOGENESIS, TERATOGENESIS AND MUTAGENESIS;1999-02
2 YANG Sheng-li, HAN Shao-yin, ZHANG Qiao, DING Lan-ping, SONG Ai-yun, GONG Ya-ou, ZHANG Tan-mu (Department of Esophageal Cancer Research, Henan Medical University, Zhengzhou 450052, China);STUDY ON THE ANTIMUTAGENICTTY OF ORIDONIN[J];Carcinogenesis,Teratogenesis and Mutagenesis;2001-01
3 XIANG Hua\+1,ZHAO Jian-zhong\+2, BO Lin\+2 (1.Hygiene and Anti-epidemic Station of Hangzhou, Hangzhou\ 310006, China; 2.Department of Cytobiology, College of Biological Sciences, Zhejiang University, Hangzhou 310009, China);STUDY ON THE ANTIMUTAGENICITY OF SEAWEED POLYSACCHARIDES[J];Carcinogenesis,Teratogenesis and Mutagenesis;2001-01
4 GUO Wei, ZHAO Ze-zhen, SHAN Bao-en, WEI Li-zhen, WEN Deng-gui(Hebei Cancer Institute, The 4+{th} Hospital of Hebei Medical University, Shijiazhuang 050011, China);REPORT ON THE ANTIMUTAGENICITY AND ANTI-TUMOR ACTIVITY OF SIX KINDS OF CHINESE MEDICINAL HERBS[J];Carcinogenesis,Teratogenesis and Mutagenesis;2002-02
5 ZHANG Chun_ling, HU Jun_feng, QU Jiang_bin, et al.(School of Public Health, Shandong University, Jinan 250012 , Ch ina);STUDY ON ANTIMUTAGENICITY OF CHINESE HERBAL MEDICINE AND GREEN TEA TO BENZOAPYRENE AND NNK[J];Carcinogenesis,Teratogenesis and Mutagenesis;2003-02
6 ZHANG Quan-xin, NIE Mu-hai (Department of Toxicology, Guangzhou Center for Diseases Prevention and control, Guangzhou 510080, China);Anti-mutagenicity test of PS8812 Polysaccharides and its Selenium Polysaccharides[J];Carcinogenesis,Teratogenesis and Mutagenesis;2004-01
7 LIU Xia,WANG Ping-jun,Xu Fu-xin (The Frist People's Hospital of Wuhu,Anhui Wuhu 241000,China);STUDY ON GYPENOSIDES INHIBITING NEOPLASM GROWTH AND ELEVATING IMMUNOLOGICAL FUNCTION IN LEWIS LUNG CANCER OF MICE[J];Journal of Anhui Traditional Chinese Medical College;2001-01
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10 Liu Bing; Wu Guangheng(Department of Medical Genetics);Study on the genetic toxicity of Radix Ophiopogonis[J];JOURNAL OF NORMAN BETHUNE UNIVERSITY OF MEDICAL SCIENCE;1999-02
【Secondary References】
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1 TANG Ting~1,YUAN Hui-ning~2,MA Jian-ping~3(1.Dept.of Pharmaceutical Analysis,Medicine and Health Management College;2.Function Laboratory,Dept.of Basic Medicine;3.Clinical Medical Colleg,Hangzhou Teachers College,Hangzhou,Zhejiang 310036,China);The preliminary study on extraction technology of gynosaponins[J];Journal of Hangzhou Teachers College(Medical Edition);2006-01
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