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《CARCINOGENESIS, TERATOGENESIS AND MUTAGENESIS》 1996-02
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MUTAGENICANDANTIMUTAGENICDETECTIONOFSODIUMBISELENITEINVITRO

Wu Jinling; Shi Genyong; Chcn Xinxia and Wang Liyun(Jiangsu Provincial Anti-Epidemic and Hygienic Station,Nanjing 210009)  
Mutagenic and antimutagenic effects of NaHSeO3 were investigatcd with Oda'sSOS/Umu chromotest,a few alterations were noticed.The results showed that the inductionratios were dcpend on the dose of NaHSeO3 at range of 0.67- 8.00mg/ml without S9 and theminimum induction dose was 1.86mg/ml,but the induction ratios were all less than 2 atrange of the doses tested with S9.The results also suggested that NaHSeO3 can significantlyinhibit theβ-galactosidase activity induced by mitomycin C(MMC)and the dose-effectcurve was in shape of parabola. From the equation of this curve,the doses of 20%,40%and60%induction of the activity were estimated to be 0. 48,1.37 and 3.21mg/ml NaHSeO3 re-spectively and the most effective dose to be 3.58mg/ml at which NaHSeO3 can inhibit 61%ofthe activity induced by MMC. These results indicated that NaHSeO3 may be a direct inductorof SOS and at the dose(below 1.86mg/ml)without mutagenicity NaHSeO3 can drastically in-hibit the SOS response induced by MMC.
【CateGory Index】: R994.6
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【Co-citations】
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