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《CARCINOGENESIS, TERATOGENESIS AND MUTAGENESIS》 1997-03
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THE DIFFERENCES OF DNA DAMAGE AND REPAIR BETWEEN SEVERAL TYPES OF CELLS

Ma Aiguo 1,Andrew R.Collins 2,Susan J.Duthie 2 1Department of Human Nutrition,Qingdao Medical College,Qingdao 266021, 2The Rowett Research Institute,U.K.  
The analysis of DNA damage and repair was made with "comet assay".The results showed that Hela,GM1899,HepG2 and fibroblast cells were more sensitive to H 2O 2 than lymphocytes from the peripheral blood.When the dosage of H 2O 2 was 100μM,the rates of DNA damage in former types of cells were 98 ̄99%;however,that of lymphocytes only was 42.1%.With regard to DNA repair,another result showed the repair rate of Hela cells with 98% DNA damage reached 90.1% after 1 hour incubation,and there was 51.1% in lymphocytes.It is suggested that there is a more repair after DNA damage in Hela cells than lymphocytes.
【CateGory Index】: Q343
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