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《CARCINOGENESIS, TERATOGENESIS AND MUTAGENESIS》 1998-05
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THE INFLUENCE OF THE THREE FREE FATTY ACIDS ON THE AFP SECRETION AND DNA SYNTHESIS OF HUMAN HEPATOCARCINOMA CELLS

Xie Litao, Huang Jiqun, Cheng Jiakun Department of Biochemistry,Guangzhou Medical College,Guangzhou\ 510182  
The purpose of this study was to investigate the inhibition effect of DNA synthesis and the AFP secretion on BEL-7402 human hepatocarcinoma cells in the presence of linolenic acid,linoleic acid and oleic acid which having the same carbon chains.The AFP concentration was determinated with radioimmunoassay,while the DNA synthesis was studied by the 3H-TdR incorporation(CPM).The results indicated that three free fatty acids could inhibite the DNA synthesis of human hepatocarcinoma cells.The effects of linolenic acid and linoleic acid(P0.01) were significant,which were stronger than that of oleic acid(P0.05). 40-50 μg/ml concentration of linolenic acid could inhibite the AFP secretion of hepatocarcinoma cells obviously compare with the blank (P 0.05).The same concentration of linoleic acid and oleic acid had no difference compare with the blank (P0.05). The conclusion showed that there was a relationship between the molecular structure and the inhibition effects of three fatty acids containing different numbers of double -bond.
【CateGory Index】: R735.703
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