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《CARCINOGENESIS, TERATOGENESIS AND MUTAGENESIS》 1998-05
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EFFECT OF VITB6 ON FREQUENCY OF SISTER CHROMATID EXCHANGE (SCE) IN VARIOUS CELLS BY USING IN VITRO AND IN VIVO ASSAY

Deng Lixia, Zheng Lukang, Zhang Qiao Lab. of Genetic Toxicology, School of Public Health, Sun Yat Sen University of Medical Sciences, Guangzhou\ 510089  
The purpose of this paper is to study the effect of VitB 6 on frequency of sister chromatid exchange(SCE) in cells from human and animals by using in Vitro and in Vivo assay. In vitro assay, the frequency of SCE was markedly increased in both cells from human lymphocytes and the Chinese hamster lung cell line (CHL), which were exposed to the VitB 6 in various doses. A dose response was presented. But in Vivo assay, the statistic difference between the SCE rates of mouse bone marrow cells in test group and in that of control group was not observed. In Vivo assay, it seems that the VitB 6 may be not a muatgen.
【CateGory Index】: Q563.3,Q343.242
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