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The Effects of Retinoic Acid on Zebrafish Embryo

Huang Bei (Department of Biology )  
Retinoic acid (RA) is well known as a biologically active form of vitamin A and a teratogen. It affects embryonic development, differentiation and tumour cell growth. The purpose here was to begin analysing the effects of RA on CNS and tailbud development in zebrafish (Brachydanio revio ). The effect of RA on zebrafish embryo is dose-dependent at wall as stage dependent. The affected embryos show microcephaly (no anteriorbrain), no eye or no heart formation and the tailbud formatiod is suppressed. but the primary reflex pathway of posterior brain and spinal cord survive. The identification of Brdu-labelled nuclei in S-phase by Brdu-anti-Brdu method suggest that RA inhibit the formation of tailbud growth zone and the embryobrain after 16 hour is unaffect by RA treatment, othersides, RA is both promote and inhibit cartilage formation depend on the conditions.
【CateGory Index】: Q954
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