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《JOURNAL OF ANHUI UNIVERSITY(NATURAL SCIENCES)》 1994-04
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The Effects of Retinoic Acid on Zebrafish Embryo

Huang Bei (Department of Biology )  
Retinoic acid (RA) is well known as a biologically active form of vitamin A and a teratogen. It affects embryonic development, differentiation and tumour cell growth. The purpose here was to begin analysing the effects of RA on CNS and tailbud development in zebrafish (Brachydanio revio ). The effect of RA on zebrafish embryo is dose-dependent at wall as stage dependent. The affected embryos show microcephaly (no anteriorbrain), no eye or no heart formation and the tailbud formatiod is suppressed. but the primary reflex pathway of posterior brain and spinal cord survive. The identification of Brdu-labelled nuclei in S-phase by Brdu-anti-Brdu method suggest that RA inhibit the formation of tailbud growth zone and the embryobrain after 16 hour is unaffect by RA treatment, othersides, RA is both promote and inhibit cartilage formation depend on the conditions.
【CateGory Index】: Q954
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【Co-references】
Chinese Journal Full-text Database 10 Hits
1 LIU Hong-ling, ZHOU Yu, XU Yan, YU Hong-xia (State Key Laboratory of Pollution Control and Resource Reuse, School of Environment, Nanjing University, Nanjing 210093, China);Investigation of toxicity effect for chlorophenols and alkyl phenols on Zebrafish Embryos[J];Journal of Safety and Environment;2004-04
2 CHANG Zhong Jie ZHOU Rong Jia YU Qi Xing (College of life sciences, Wuhan University, Wuhan 430072,China);GENETIC VARIATION OF TWO LOACH SPECIES REVEALED BY RAPD ANALYSIS[J];Acta Zoologica Sinica;2001-01
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6 ZHOU Yu,ZHANG Jun hui,YANG Zhen guo,ZHU Shi cheng,ZHANG Kai,FENG Xian wei (Faculty of Animal Sciences and Veterinary Medicine,The Quartermaster University of PLA,Changchun 130062,China);Effects of Temperature and Illuminance on Embryonic Development of Fresh Angelfish,Pterophyllum scalare[J];Fisheries Science;2001-03
7 XU Zhen, JIANG Jin-po (Faculty of Life Science and Biotechnology, Ningbo University, Ningbo 315211, China);Effects of Cerium on Embryonic Development of Large Yellow Croaker, Pseudosciaena crocea (Richardson)[J];Fisheries Science;2004-12
8 YI Le-fei~1, LIU Chu-wu~2(1.Department of Ocean, Huaihai Institute of Technology, Lianyungang 222042, China;2.Fisheries College, Zhanjiang Ocean University, Zhanjiang 524025, China);RAPD Analysis of Four Snapper Species[J];Fisheries Science;2005-01
9 Pan Weizhi, Chen Jun, Zhao Chungang, Wang Peng, Wang Bingqian(Heilongjiang River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Harbin 150070, P. R. China);Embryonic Development of Hybrid Silurus asotus (Silurus soldatovi♀×Silurus asotus♂)[J];Journal of Northeast Forestry University;2004-06
10 WU Qing, WANG Qiang, CAI Li-ming, DAI Chang-hua, LU Jian-ping (Faculty of Fishery Southwest Agricultural University, Chongqing 402460,China);The embryonic and larval development of Sclizothorax prenanti[J];Journal of Dalian Fisheries University;2004-03
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