Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《畜牧与饲料科学(英文版)》 2009-03
Add to Favorite Get Latest Update

Pharmacokinetics of Junmie for Novel Antibacterial Medicine in Rabbits

LI Jian-yong1, 2*, TANG Feng3, ZHOU Xu-zheng1, 2, ZHANG Ji-yu1, 2, NIU Jian-rong1, 2, WEI Xiao-juan1, 2, YANG Ya-jun1, 2 1. Lanzhou Institute of Animal and Veterinary Pharmaceutics Sciences, CAAS, Lanzhou 730050, China; 2. Key Lab of New Animal Drug Project, CAAS, Lanzhou 730050, China; 3. Animal Science and Veterinary Medicine, Liaoning College of Medicine, Jinzhou 121000, China  
[Objective] The paper presents the pharmacokinetics of Junmie in healthy rabbits and thus provides a basis for its rational application. [Method] HPLC method was developed to detect the concentration of Junmie with benzoyl ciprofloxacin as internal standard. After the healthy rabbits was respectively injected Junmie intravenously and intramuscularly, plasma concentration after injection was detected with the established HPLC method so as to determine the best pharmacokinetic model. [Result] The conditions of HPLC were as follows: mobile phase was 100 ml 60% (V/V) methanol solution (pH 3.0); flow rate was 1.0 ml/min; column temperature was (25.0±0.5) ℃; detection wavelength was 278 nm. The concentration-time data of the plasma, collected from intravenously and intramuscularly injected rabbits, was separately in line with the two compartments and one compartment open model with the first order absorption. The main pharmacokinetic parameters of the plasma sample (i.v.) were as below: T1/2α= 0.07 h, T1/2β = 0.82 h, AUC = 3.51 mg/(L·h), CLB = 4.57 L/(kg·h); the plasma sample (i.m.): T1/2α= 0.33 h, T1/2k = 0.33 h, Tp = 0.6 h, Cmax = 2.55 μg/ml, AUC = 4.87 mg/(L·h). The bioavailability was approximately 110%. [Conclusion] After intramuscular administration, Junmie is absorbed and eliminated quickly with high bioavailability and extensive distribution.
【Fund】: 中国农业科学院科研基金项目(20041001)~~
【CateGory Index】: S859.79
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【Citations】
Chinese Journal Full-text Database 3 Hits
1 GUO Hui-Yuan, TANG Yun, LI Zhuo-Rong, YAN Gui-Hua and ZHANG Zhi-Ping (Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences, Beijing);STUDIES ON PYRIDONECARBOXYLIC ACIDS AS ANTIBACTERIAL AGENTS V. SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF PIVALOYLOXYMETHYL 1-ETHYL-6-FLUORO-1, 4-DIHYDRO-4-OXO-7-(4-METHYL-1-PIPERAZINYL) QUINOLINE-3-CARBOXYLATE AND ITS ANALOGUES[J];Acta Pharmaceutica Sinica;1987-05
2 XS Jia, YL Wang~*, FS He~(**), YF Shan~(**), YF Li~(**) and Y Wang~(***)(Department of Chemistry, Henan Normal University, Xinxiang 453002; ~(**)Department of Biology, Henan Normal University, Xinxiang 453002);SYNTHESIS AND ANTIBACTERIAL ACTION OF 1-ETHYL-6-FLUORO-1, 4-DIHYDRO- 4-OXO-7-(4-AROYLTHIOCARBAMOYL-1 -PIPERAZINYL)- 3-QUINOLINE CARBOXYLIC ACIDS[J];Acta Pharmaceutica Sinica;1993-06
3 Yang Shu qun 1, He Hai xia 2 and Zhou Yuan da 2 (1 The Second Affiliated Hopsital, Chongqing Medical University, Chongqing 400010; 2 The First Affiliated Hopsital, Chongqing Medical University, Chongqing 400016);Distribution and pharmacokinetics after intravenous injection of ciprofloxacin in the rabbit eye[J];Chinese Journal of Antibiotics;2002-07
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 LI Jian-yong et al(Lanzhou Institute of Animal and Veterinary Pharmaceutics Sciences,CAAS,Lanzhou,Gansu 730050);Pharmacokinetics of Junmie for Novel Antibacterial Medicine in Rabbit[J];Journal of Anhui Agricultural Sciences;2009-18
2 LI Jian-yong,LI Hong-sheng,ZHOU Xu-zheng,ZHANG Ji-yu,NIU Jian-rong,LI Jin-shan,WEI Xiao-juan(Lanzhou Institute of Animal and Veterinary Pharmaceutics Sciences,CAAS,Lanzhou,Gansu,730050,China);Primary Test on Activity of Junmie Against Bacteria[J];Progress in Veterinary Medicine;2006-08
3 YANGShuqun, et al (Dept. of Ophthalmology, The Second College of Clinical Medicine, Chongqing Universty of Medical Sciences, 400010);Distribution and pharmacokinetics after intravenous injection of ciprofloxacin in the rabbit eye[J];Journal of Pediatric Pharmacy;2000-02
4 ZHOU Bei,LIN Xiao-Feng,WU Wei,YE Mao-Guo,HU Dong-Mei,LI Qing From the Department of Ophthalmology,Tianhe Central Hospital(ZHOU Bei,YE Mao-Guo,HU Dong-Mei),Guangzhou 510655,Guangdong Province,China;Zhongshan Ophthalmic Center,Sun Yat-sen University(LIN Xiao-Feng,WU Wei,LI Qing),Guangzhou 510060,Guangdong Province,China;Ligustrazine on ocular endosmosis of ciprofloxacin in rabbit eyes of corneal perforating injury[J];Recent Advances in Ophthalmology;2008-02
5 LI, Ying-Jun*,a LIU, Su-Naa XU, Yong-Tinga JIN, Kunb PENG, Qin-Jib WANG, Yinga ZHANG, Zhi-Guanga (aSchool of Chemical Engineering, Liaoning Normal University, Dalian 1160290) (bState Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116012);Synthesis and Antibacterial Activity of 1-Cyclopropyl-6-fluoro-7-(4-acyl-1-piperazinyl)-1,4-dihydro-4-oxo-quinoline-3-carboxylic Acid[J];Chinese Journal of Organic Chemistry;2005-10
6 Dai Guiyuan;Shi Daqing; Zhou Longhu and Wang Shuliang(Department of Chemistry ,Xuzhou Teachers College),Xuzhou 221009;Synthesis of 1-Aroyl-3-(4-Benzosulfonamide)-TMoureas[J];CHINESE JOURNAL OF APPLIED CHEMISTRY;1994-06
7 ZHOU Yuanda,HE Haixia(Clinical Pharmacology Laboratory, The First Affiliated Hospital of Chongqing University of Medical Sciences, Chongqing 400016,China)HAN Min,ZHE Xuejun,WU Yan(Dept. of Pharmacy, The First Affiliated Hospital of Chongqing University of Medical Sciences, Chongqing 400016,China);Study on the Distribution of Gatifloxacin in Ocular Tissues and Its Pharmacokineties in Rabbit[J];China Pharmacy;2005-06
8 QU Ling bo,TIAN Meng chao,CHANG Jun biao,CHEN Rong feng,GUO Zong ru (Department of Chemistry,Zhengzhou University,Zhengzou 450052,China);Studies on the synthesis and antibacterial activity of quinolone analogues[J];Chinese Journal of Medicinal Chemistry;2002-04
9 TIAN Meng chao,QU Ling bo,XIE Jian gang,CHEN Rong feng (Department of Chemistry,Zhengzhou University,Zhengzhou 450052,China);Syntheses and antibacterial activity of 1-alkyl-6-fluoro-7-(4-acyl-1-piperazinyl)-1,4-dihydro-4-oxo- quinoline-3-carboxylic acid and its derivatives[J];Chinese Journal of Medicinal Chemistry;2002-05
10 YE Fa-qing 1,DING You-mei 1,YE Song 2,YUAN Xin 2 (1.Department of Pharmaceutical Chemistry,Wenzhou Medical College,Wenzhou 325027,China; 2.Department of Pharmacy,Xianning Medical College,Xianning 437100,China);Synthesis and antibacterial activity of norfloxacin derivatives[J];Chinese Journal of Medicinal Chemistry;2003-03
China Proceedings of conference Full-text Database 1 Hits
1 LI Jian-yong~1 TANG Feng~2 ZHOU Xu-zheng~1 ZHANG Ji-yu~1 NIU Jian-rong~1 WEI Xiao-juan~1 (Lanzhou Institute of Animal and Veterinary Pharmaceutics Sciences,Chinese Academy of Agricultural Sciences,Lanzhou 730050);The Pharmacokinetics of Junmie in Rabbits[A];[C];2008
【Secondary Citations】
Chinese Journal Full-text Database 4 Hits
1 JIA Xue-Shun;WANG Yu-Lu;LI Yong-Fang;HE Fang-Shu;SHAN Ying-Fang Department of Chemistry, Henan Normal University, 453002 Xinxiang, Henan Department of biology, Henan Normal University, 453002 Xinxiang, Henan;Synthesis of 1-Aroyl-3-(4-Benzosulfonamidopyrimidine)-thioureas[J];Chinese Journal of Organic cHEMISTRY;1993-03
2 GUO Hui-Yuan CAO Yi-Chen SUN Lan-Ying MIAO Hua ZHANG Zhi-Ping (Institute of Medicinal Biotechnology,Chinese Academy of Medical Sciences,Beijing 100050);SYNTHESIS OF NORFLOXACIN FROM 3,4-DIFLUOROANILINE[J];Chinese Journal of Pharmaceuticals;1992-01
3 JI Geng-Hao (Shenzhen Sinor Pharmaceutical Co.Ltd.Guangdong 518003);SURVEY ON SYNTHETIC PROCESS OF NORFLOXACIN[J];Chinese Journal of Pharmaceuticals;1992-03
4 Zhang Zhi-ping (Institute of Antibiotics. Chinese Academy of Medical Sciences, Beijing);PROGRESS IN STUDIES ON TOTAL SYNTHESES OF ANTIBIOTICS AND ANTIMICROBIAL AGENTS IN THE 1980S.[J];;1985-03
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved