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《畜牧与饲料科学(英文版)》 2009-03
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Pharmacokinetics of Junmie for Novel Antibacterial Medicine in Rabbits

LI Jian-yong1, 2*, TANG Feng3, ZHOU Xu-zheng1, 2, ZHANG Ji-yu1, 2, NIU Jian-rong1, 2, WEI Xiao-juan1, 2, YANG Ya-jun1, 2 1. Lanzhou Institute of Animal and Veterinary Pharmaceutics Sciences, CAAS, Lanzhou 730050, China; 2. Key Lab of New Animal Drug Project, CAAS, Lanzhou 730050, China; 3. Animal Science and Veterinary Medicine, Liaoning College of Medicine, Jinzhou 121000, China  
[Objective] The paper presents the pharmacokinetics of Junmie in healthy rabbits and thus provides a basis for its rational application. [Method] HPLC method was developed to detect the concentration of Junmie with benzoyl ciprofloxacin as internal standard. After the healthy rabbits was respectively injected Junmie intravenously and intramuscularly, plasma concentration after injection was detected with the established HPLC method so as to determine the best pharmacokinetic model. [Result] The conditions of HPLC were as follows: mobile phase was 100 ml 60% (V/V) methanol solution (pH 3.0); flow rate was 1.0 ml/min; column temperature was (25.0±0.5) ℃; detection wavelength was 278 nm. The concentration-time data of the plasma, collected from intravenously and intramuscularly injected rabbits, was separately in line with the two compartments and one compartment open model with the first order absorption. The main pharmacokinetic parameters of the plasma sample (i.v.) were as below: T1/2α= 0.07 h, T1/2β = 0.82 h, AUC = 3.51 mg/(L·h), CLB = 4.57 L/(kg·h); the plasma sample (i.m.): T1/2α= 0.33 h, T1/2k = 0.33 h, Tp = 0.6 h, Cmax = 2.55 μg/ml, AUC = 4.87 mg/(L·h). The bioavailability was approximately 110%. [Conclusion] After intramuscular administration, Junmie is absorbed and eliminated quickly with high bioavailability and extensive distribution.
【Fund】: 中国农业科学院科研基金项目(20041001)~~
【CateGory Index】: S859.79
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