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《Journal of Anhui Agricultural Sciences》 2006-06
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Protection of Antioxidants Supplement in Oxidative Stress of Rat Fed with High-fat Diet

LI An-lin et al(Key Laboratory of Food Science and Safety,Ministry of Education,School of Food Science and Technology,Southern Yangtze University,Wuxi,Jiangsu 214036)  
The effects of Lipoic acid(LA) and N-acetyicysteine(NAC)on oxidative stress of rats fed with high-fat diet were explored.32 SD male rats were divided into 4 groups: control group,high-fat group,high-fat + LA group(0.1 %) and high-fat + NAC group(0.1 %).The results showed that high-fat diet could result in rat oxidative stress and reduce antioxidation capability of rat significantly.In contrast to high-fat group,both activities of SOD in serum and the content of T-AOC and GSH in serum and tissue were increased significantly in LA or NAC groups and MDA,decreased significantly.Single cell gel electrophoresis essay showed LA and NAC could decrease liver mitochondrial DNA damage of rats with fed high-fat diet significantly.Moreover,the effect of LA were better than those of NAC.The conclusions were LA and NAC can improve the antioxidation capability,suppress lipid peroxidation and prevent liver mitochondrial DNA damage of rats fed high-fat diet.
【Fund】: 国家自然科学基金(30571347)
【CateGory Index】: S816.7
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