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《Journal of Anhui Agricultural Sciences》 2008-09
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Experiment on Acute Toxicity of Ionic Liquid 1-octyl-3-methylimidazolium Bromide to Mice

YU Miao et al(College of Life Science,Henan Normal University,Xinxiang,Henan 453007)  
[Objective] The research aimed to provide reference for further study on the toxicity of ionic liquid to mice and other mammals.[Method]With male and female Kunming mice as tested animals,the acute toxicity of ionic liquid 1-octyl-3-methylimidazolium bromide(Br) to mice after intraperitoneal injection was determined by the improved Karber's method.[Result] Ionic liquid Br caused the death of some mice,with the median lethal dose(LD50) after 24 h to female and male mice being 52.27 and 35.24 mg/kg resp.Br had medium toxicity and the sensitivity of female mice was higher than male mice.In middle-dose group,the liver tissue of mice was obviously damaged and obvious cytoplasmic vacuoles were produced.[Conclusion] Liver played certain functions in resisting the toxicity of [C8mim]Br.
【Fund】: 河南师范大学科研基金项目(052063);; 河南省动物学省级重点学科基金项目
【CateGory Index】: R363
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