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《Journal of Anhui Agricultural Sciences》 2008-33
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Study on Antitumor Activity and Immunomodulating Effect of Polysaccharides Isolated from Solanum nigrum Linne

LI Jian et al(College of Enviroment and Chemical Engineering,Yanshan University,Qinhuangdao,Hebei 610400)  
[Objective] The research aimed to study the effects of polysaccharides isolated from Solanum nigrum Linne(SNL-P) on the growth of U14 cervical cancer and the immunomodulating activity on the tumor bearing mice.[Method] Growth inhibition of U14 cells in vitro by SNL-P was measured using MTT assay,the inhibition rate of ascites tumor growth and increment rate of life span were measured,and the effects of SNL-P on the level of IL-4,IFN-γ in serum of tumor bearing mice were examined by ELISA method after the cervical cancer harboring models in mice were established and treated with SNL-P.[Result] SNL-P showed strong inhibition effects on the U14 tumor growth and could prolong the survival time of tumor bearing mice.Cytokine assay further showed that SNL-P treatment could increase the level of IFN-γ and decrease the level of IL-4 in serum of tumor bearing mice significantly.[Conclusion] SNL-P possessed the activity of inhibiting the growth of U14 ascites cervical cancer and prolonging the survival time of tumor harboring mice.It was conjectured that SNL-P might exert its anti-tumor effects by activating the activity of the immune system of tumor harboring mice and further modulating the secretion of cytokines.
【Fund】: 秦皇岛市科技攻关重点项目(D08)
【CateGory Index】: R285
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