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《Journal of Anhui Agricultural Sciences》 2009-04
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Study on Palladium-catalyzed Suzuki Cross-coupling Reaction in Aqueous Phase and Its Application in Synthesis of Bifenthrin

GU Wei-na et al(School of Chemical Engineering,Shijiazhuang University,Shijiazhuang,Hebei 050035)  
[Objective] The purpose was to study the palladium-catalyzed suzuki cross-coupling reaction in aqueous phase and its application in synthesis of bifenthrin.[Method] The synthesis of bifenthrin intermediate(biphenyl derivatives)of Pd-catalyzed suzuki cross-coupling reaction in aqueous phase was researched by adding surfactant instead of water soluble phosphine ligand(tris(3-sulfonatophenyl)phosphine sodium salt,TPPTS).[Result]The results showed that the catalytic activity of the system ionic surfactant/Pd(OAc)2 was better than the system TPPTS/Pd(OAc)2.The catalytic effect of anionic surfactant(sodium dodecyl sulfate,SDS) was better than cationic surfactant(cetyltrimethylammonium bromide,CTAB) and nonionic surfactant(polyethylene glycol-400,PEG-400).When aqueous phase,1.0 mol% Pd(OAc)2,K2CO3 and SDS were used,the yield was 98% for 4-bromotoluene with phenylboronic acid in one hour.In the presence of 0.1 mol% palladium acetate,76% yields were isolated in six hours.[Conclusion]The targer product was 4-Methyl-biphenyl which was charactered by 1H NMR.
【Fund】: 河北省教育厅科学研究课题(Z2008478);; 石家庄市科学技术研究与发展指导计划(07149651);; 石家庄学院博士基金(2008)
【CateGory Index】: TQ453.2
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