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《Journal of Anhui Agricultural Sciences》 2009-05
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Detection on the Residues of Lincomycin in Honey by LC-ESI-MS/MS

RUAN Xiang-chun et al (College of Animal Sciences,Anhui Agricultural University,Hefei,Anhui 230036)  
[Objective] The purpose was to set up the method of detecting the residues of lincomycin in honey by HPLC-ESI-MS/MS.[Method] The samples purified by solid-phase extraction and isolated by liquid-phase extraction were analyzed by MS.The signal collection of characteristic maternal ions and sub-ion pairs was conducted in MRM.The qualitative analysis was conducted on the basis of retaining time,maternal ions and the two characteristic sub-ions.The quantification was conducted on base-peak ion m/z126,whose ion peak was most intense.[Result] In the linear scope of 1.0-20.0 ng/ml,the peak-intensity had good linear correlation with added concn.(r20.999 6).Under the 3 addition levels of 2.5, 5.0 and 10.0 ng/g,the average recovery of lincomycin was(95.1±3.3)%,the RSD of determination results during one day was smaller than 5.3%,that between two days was smaller than 8.5%,with detection limit being 0.1 ng/g.[Conclusion] HPLCESI-MS/MS was a sensitive and precise method in detecting the residues of lincomycin in honey and met the requirements of residues analysis on lincomycin.
【CateGory Index】: S896.1
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