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《Journal of Anhui Agricultural Sciences》 2009-07
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Effect of Podophyllum emodi Polysaccharide on Antioxidant Capacities in Immunosuppressed Mice

HU Ting-jun et al(College of Animal Science and Technology,Guangxi University,Nanning,Guangxi 530005)  
[Objective]The purpose of this research was to discuss the effect of Podophyllum emodi polysaccharide on antioxidant capacities in immunosuppressed mice.[Method]Spleen index,the thymus index,GSH levels,T-SOD activities,TAOC,MDA level and NO levels in mice treated with PEP alone or both PEP and dexamethasone(Dex) were measured.[Result]The results indicated that the vivo investigation demonstrated that intraperitoneal administration of PEP raised spleen indice,thymus glutathione levels,plasma total antioxidant capacities and reduced splenic MDA levels in normal animals and NO levels of spleen in immunosuppressed mice.[Conclusion]The PEP,possessing pronounced free radical scavenging and antioxidant activities,which may play an important role in preventing from oxidative damage to immunological system.
【Fund】: 国家自然科学基金资助项目(30371056);; 广西大学科研基金资助项目“中药多糖对机体免疫系统功能调节及信号机制研究”(X071026)
【CateGory Index】: S853.7
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