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《Journal of Anhui Agricultural Sciences》 2009-13
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Effects of Chanfukang(Chinese Medicine) on the Cytokine Level of Immunosuppressive Mouse

MI Bao-ming et al (Animal Medical College,Gansu Agricultural University,Lanzhou,Gansu 730070)  
[Objective] The research aimed to study the effects of Chanfukang on the cytokines of immunosuppressive mice,providing the basis for the further research of its effects on immune function.[Method] Immunosuppressive mouse model was established through twice intraperitoneal injection with cyclophosphamide at the dose of 40 mg/kg.After the mice were gavaged respectively with Chanfukang at the dose of 10,15 and 20 g/kg,the level of cytokines(IL-1β,IL-2 and TNF α) were detected.[Result] Chanfukang significantly increased the level of IL-1β,IL-2 and TNF α in the serum of mice gavaged only with Chanfukang;the level of IL-1β,IL2 and TNF α was inhibited in mice treated with cyclophosphamide;Chanfukang significantly increased the level of IL-1β,IL-2 and TNF α in the serum of immunosuppressive mice.[Conclusion] Chanfukang should antagonize the immunosuppression of cyclophosphamide and improve the immune function.
【Fund】: 国家科技攻关项目奶业专项“奶牛主要疫病防治关键技术研究与产业化开发”子课题“预防奶牛子宫内膜炎中药或中西结合药剂的研制”(2002BA518A04)资助
【CateGory Index】: S853.7
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