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《Journal of Anhui Agricultural Sciences》 2009-20
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Study on Antitumor Effect in vitro of Different Extractions by Water from Roots of Glehnia littoralis

LIU Xi-ling et al (Qingdao Agricultural University,Qingdao,Shandong 266109)  
[Objective] Antitumor effect in vitro of different extractions from roots of Glehnia littoralis were studied.[Method] The three extractions,which were obtained by water from roots of Glehnia littoralis and treated by alcohol,had in vitro pharmacological effect on lung cancer cell line(A549),stomach cancer cell line(SGC) and liver cancer cell line(HEP).[Result] Different concentrations of the three extractions had anticancer activities on liver cancer cell line(HEP).There wasn't significant difference among different concentrations of dissolved matter in water and alcohol and dissolved matter only in water.When the concentration of dissolved matter only in alcohol was 300.000 μg/ml,its inhibitory rate significantly higher than others.Most concentrations of the three extractions had anticancer activities on lung cancer cell line(A549).When the concentration of dissolved matter in water and alcohol was 37.500 μg/ml,its inhibitory rate was significantly higher than others.There wasn't significant difference among different concentrations of dissolved matter only in water.When the two concentrations of dissolved matter only in alcohol were 75.000 μg/ml and 18.750 μg/ml,their inhibitory rates were significantly higher than others.Only concentration of the dissolved matter in alcohol was 300.000 μg/ml,had anticancer activities on stomach cancer cell line(SGC),and its inhibitory rate was only 6.340%.The other two extractions hadn't anticancer activities on stomach cancer cell line(SGC).[Conclusion] Three extractions obtained by water and alcohol from roots of Glehnia littoralis had anticancer activities effects on liver cancer cell line(HEP) and lung cancer cell line(A549),but they almost had no inhibitory effects of anticancer activities on stomach cancer cell line(SGC).
【Fund】: 山东省自然科学基金项目(Y2008D45)
【CateGory Index】: R285.5
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