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《Journal of Anhui Agricultural Sciences》 2009-23
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Influences of Isocitrate Lyase Inhibitors on the Synthesis of L-Glutamate

YU Bing-qi et al(Department of Biological and Pharmaceutical Engineering,College of Chemistry and Chemical Engineering,Jiangsu Polytechnic University,Changzhou,Jiangsu 213164)  
[Objective] The purpose was to research the influences of succinic acid and malic acid on the synthesis of L-glutamate.[Method] With the typical strain Corynebacterium glutamicum ATCC 13032 of Corynebacterium glutamate as tested strain,the influences of succinic acid and malic acid on cell growth,synthesis of L-glutamate,residual sugar content in fermentation broth and activity of isocitrate lyase in cell were researched.[Result] The succinic acid had partial inhibition on the activity of isocitrate lyase.In the range of 0-5.0 g/L,the addition of succinic acid enhanced the glucose acid invert ratio of L-glutamate fermentation,the cell growth and secretion of L-glutamate were inhibited and the residual sugar content was increased.The addition of malic acid decreased the activity of isocitrate lyase and the output of L-glutamate and the residual sugar content and cell growth had no obvious regular change.When 2.0 g/L succinic acid and 2.0 g/L malic acid were added simultaneously,both the activity of isocitrate lyase and cell growth got decreased a little and the output of L-glutamate and residual sugar content had no obvious change.[Conclusion] The addition of succinic acid increased the output of L-glutamate and the addition of malic acid decreased the output of L-glutamate.
【CateGory Index】: R914
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