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《Journal of Anhui Agricultural Sciences》 2009-23
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Influences of Isocitrate Lyase Inhibitors on the Synthesis of L-Glutamate

YU Bing-qi et al(Department of Biological and Pharmaceutical Engineering,College of Chemistry and Chemical Engineering,Jiangsu Polytechnic University,Changzhou,Jiangsu 213164)  
[Objective] The purpose was to research the influences of succinic acid and malic acid on the synthesis of L-glutamate.[Method] With the typical strain Corynebacterium glutamicum ATCC 13032 of Corynebacterium glutamate as tested strain,the influences of succinic acid and malic acid on cell growth,synthesis of L-glutamate,residual sugar content in fermentation broth and activity of isocitrate lyase in cell were researched.[Result] The succinic acid had partial inhibition on the activity of isocitrate lyase.In the range of 0-5.0 g/L,the addition of succinic acid enhanced the glucose acid invert ratio of L-glutamate fermentation,the cell growth and secretion of L-glutamate were inhibited and the residual sugar content was increased.The addition of malic acid decreased the activity of isocitrate lyase and the output of L-glutamate and the residual sugar content and cell growth had no obvious regular change.When 2.0 g/L succinic acid and 2.0 g/L malic acid were added simultaneously,both the activity of isocitrate lyase and cell growth got decreased a little and the output of L-glutamate and residual sugar content had no obvious change.[Conclusion] The addition of succinic acid increased the output of L-glutamate and the addition of malic acid decreased the output of L-glutamate.
【CateGory Index】: R914
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【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 WANG Gui-lan et al(College of Life Science and Pharmacy,Nanjing University of Technology,Nanjing,Jiangsu 210009);Effects of Exogenous Supplement on Fermentative Production of Fumaric Acid by Rhizopupus oryzae[J];Journal of Anhui Agricultural Sciences;2009-08
2 WANG Jian, CHEN Ning, TAN Qing-qiao, ZHANG Ke-xu (College of Food Science and Bioengineering, Tianjin University of Science and Technology, Tianjin 300222, China);Study on Breeding of L-tryptophan-producing Strain and Its Fermentation Conditions[J];Amino Acids & Biotic Resources;2003-03
3 LIU Jian-jun,ZHAO Xiang-ying,TIAN Yan-jun,LI Pi-wu,ZHANG Jia-xiang, LIU Li-ping,HAN yian-lei,MA Chuen-ling ( Food &Fermentation Engineering Key Lab of Shandong Province, Jinan 250013, China);Application of L-Leucine and The Breeding Idea[J];Amino Acids & Biotic Resources;2004-04
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7 WU Xiao-wei~1,WU Zhi-guo~1,WANG Yan-min~1,DONG Chao~2,ZHANG Li-ping~2,SHI Yan-mao~2,CHANG Qing~3(1.Hebei University of Technology, Tianjin 300130 China;2.Hebei Insititute of Biology,Shijiazhuang Hebei 050081 China;3.Tangshan City No.4 Middle School,Tangshan Hebei 063000,China);Ultraviolet induced mutation of methamidophos degradating bacterium and selection of prolific bacterium[J];Journal of The Hebei Academy of Sciences;2005-03
8 Zhang Hua Du Haiyan Sun Jiayue Li Ning~*(College of Chemistry and Environment Engineering,Beijing Techmology and Business University,Beijing 100037;*.Beijing Ganghua Auxiliary Ltd.Co.Beijing 100018);Last Decade Progress for Synthesis of the Pyruvic Acid and Pyruvate[J];Chemical Industry Times;2006-05
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10 LIU Yong mei 1, WANG Zhong shi 1, WANG Huan zhang 1, CHU Ju 2* , CAI Xian peng 2, CHEN Shuang xi 2 (1. Star Lake Bioscience Co. Inc., Zhaoqing, Guangdong 526060, China; 2. State Key Laboratory of Bioreactor Engineering ECUST, Shangha;Relationship Between DO Level, OUR and Guanosine Accumulation in Guanosine Fermentation[J];Journal of East China University of Science and Technology;2002-03
【Secondary Citations】
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1 LIU Li-ming, LI Yin, DU Guo-cheng, QIAN Qi-feng, CHEN Jian (Key Lab of Industrial Biotechnology, Ministry of Education, Southern Yangtze University, Wuxi 214036);Breeding of high-pyruvate-producing Torulopsis glabrata with acetate as supplement carbon source[J];Industrial Microbiology;2002-03
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