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《Journal of Anhui Agricultural Sciences》 2010-09
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Hepatoprotective Effects of Phenolic Acid from Salvia chinensis Benth. on Carbon Tetrachloride-Induced Acute Liver Injury in Mice

CHEN Peng et al (Ocean School of Yantai University,Yantai,Shandong 264005)  
[Objective] To study the protective effect of phenolic acid from Salvia chinensis Benth. (PAS) against CCl4-induced acute liver injury in mice and its possible mechanism. [Method] Mice were divided into control group,model group randomly,Salvia chinensis Benth. was divided into 6 groups such as high,medium and low-dose treatment group and positive group (Silibinin). Mice were pretreated by phenolic acid (i.g) for 5 days. Hepatic injury was induced by injecting 1 ml/kg 50% peanut oil solution of carbon tetrachloride,the contents of AST,ALT,T-AOC,MDA,GSH were determined after 24 h. [Result] Compared with model group,serum AST,ALT in PAS high,medium and low-dose groups reduced significantly; total antioxidant capacity (T-AOC),reduced gluthione (GSH) increased,as well as MDA content decreased significantly,all above indexes changed in a dose-dependent way. Histopathological study showed that the protective effects of the PSA also indicated a dose-dependent manner. [Conclusion] The PAS has a protective effect on the carbon tetrachloride induced acute liver injury in mice,hepatoprotective effects of PAS may be related to its antioxidant characteristic. Total phenolic acids of Salvia chinensis Benth. can enhance anti-oxidant capacity of organizations,reduce carbon tetrachloride induced lipid peroxidation,and protect cell membranes from damage.
【Fund】: 国家十一五支撑计划资助课题(2006BAI06A18);; 教育部新世纪优秀人才支持计划资助项目(NCET-06-0918)
【CateGory Index】: R285.5
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