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《Journal of Anhui Agricultural Sciences》 2010-20
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Study on the Anti-platelet Aggregation and Anticoagulant Activities of Extracts from Compound Flower

WU Guan-zhong et al(Department of Pharmacology,Chinese Pharmaceutical University,Nanjing,Jiangsu 210009)  
[Objective] This study was undertaken to evaluate the effect of compound flower extracts of Rosa rugosa and Rose chinensis Jacq.on platelet aggregation and blood system.[Method] The effects of compound flower extracts on whole blood aggregation in rabbit,platelet aggregation in vitro,prothrombin time and activated partial thromboplastin time and fibrinolysis sgstem of rats were investigated.Using high-glucose induced human umbilical vein endothelial cell damage model,its effects on the SOD activity and MDA contents in the cell were studied.[Result] Platelet aggregation in whole blood of rabbits can be inhibited by compound flower extracts.In coagulation assay,compound flower extracts prolonged the coagulation time of whole blood,decreased euglobulin clot lysis assay and the content of fibrinogen.[Conclusion] Compound flower extracts had the anti-platelet aggregation and anticoagulant activities.
【Key Words】： Compound flower extracts Platelet aggregation Anticoagulant activity
【CateGory Index】： S685.12
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