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《Journal of Anhui Agricultural Sciences》 2011-01
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Research on Pathology of Piglets Infected with GXA Strain of PRRSV

WEI Ying-yi et al (College of Animal Science and Technology,Guangxi University,Nanning,Guangxi 530005)  
[Objective] To investigate the pathgenicity of piglets infected with PRRSV GXA strain.[Method] A total of 12 4-week-old healthy piglets which were negative of antibody and antigen of PRRSV/PCV2 were randomly divided into challenge group(9 piglets) and control group(3 piglets).GXA strain of PRRSV(4 ml/head) was inoculated intranasally and intranscularly simultaneously and cell culture medium of non RRRSV(4 ml/head) was inoculated in conteol group.Three piglets(in challenge group ) and one piglet(in control group) were killed individually in 11,14 and 21 d after starting experiment.Pathogenicity was evaluated by temperature detection,clinical symptom,pathological,specific antibody and viral nucleic acid.[Results] Rectal temperature increased lightly at 6 d post-infection and then to regain normal.GXA strain of PRRSV caused no obviously clinical signs.Pathological change was only observed in two infected piglets at 21 d post-infection,which characterized as small focal interstitial pneumonia in lung.The histological lesions of PRRSV infected piglets were characterized by infiltration of macrophages and lymphocytes in alveolar septum.Challenge group produced a higher level of special-antibody titres and PEESV DNA had been detected.[Conclusion]The pathological lesions were milder in piglets infected PRRSV GXA strain.
【Fund】: 广西大学科研基金(X051013)项目资助
【CateGory Index】: S858.28
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