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Pathogenesis of Bovine Brucellosis

WANG Jing-long et al(College of Animal Science and Veterinary Medicine,Jilin University,Changchun Jilin 130062)  
Bovine brucellosis is one of the most important zoonotic diseases worldwide,and is widely spread in developing countries.The disease,which results in serious economic losses due to late term abortion,stillborn and weakly calves,is caused by Gram negative coccobacilli bacteria of the genus Brucella.Lesions consist of necrotic placentitis and interstitial mastitis in pregnant cows,and fibrinous pleuritis with interstitial pneumonia in aborted fetuses and newborn calves.The pathogenesis of Brucella abortus and the ability of the pathogen to invade phagocytic and nonphagocytic host cells,resist the acidified intraphagosomal environment,and inhibit phagosome–lysosome fusion were expounded.Significant aspects of innate and adaptive immunity against brucellosis were also discussed.
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