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《Journal of Anhui Agricultural Sciences》 2011-16
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Study on Comparison of the Immune of Thymus and Spleen between Male and Female Mice

ZHENG Guo-qiang et al(College of Food Engineering and Biotechnology,Tianjin University of Science and Technology,Tianjin 300457)  
[Objective] The experiment was conducted to explore the immune differences between male and female mice.[Method] Taking eight weeks old female and male mice as study object,the weight and index of thymus and spleen were measured.HE staining and flow cytometry were performed to observe histomorphological changes and the percentage of CD3,CD4,CD8 and CD19 lymphocytes.[Result] The results showed that the weight and index of thymus of female mice were significantly larger than that of male mice(P0.05).The morphology structure of spleen in female mice was more complete than that in male mice.The percentages of CD4+CD8+ in the thymus in female mice were higher than that in male mice(P0.01).The percentages of CD4+CD8+ cell in male mice were fairly fewer than that in male mice(P0.05).The percentages of single lymphocyte CD4+CD8+ cell in male femice was obviously lower than that in the female mice(P0.01).[Conclusion] There were immune differences between male and female mice,and especially the differences in thymus aspects were more apparent.
【Fund】: 国家自然科学基金项目(20776113);; 天津科技大学科学研究基金项目(20090207)
【CateGory Index】: S865.13
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