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《Journal of Anhui Agricultural Sciences》 2013-15
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Study on Antiproliferative Activity of Ruditapes philippinarum Hydrolysate on Human Prostate Cancer DU-145 Cell

LI Lian-jun et al(School of Food Science and Pharmacy of Zhejiang Ocean University,Zhejiang Provincial Key Engineering Technology Research Center of Marine Biomedical Products,Zhoushan,Zhejiang 316004)  
[Objective] To study Philippines clam enzymolysis peptide on prostate cancer DU-145 cells proliferation activity in vitro.[Method] Digestive enzyme was used to enzymolysis the Philippine clam guts,3 kD molecular weight cut-off membranes were used to fractionate the Ruditapes philippinarum hydrolysate.The anti-proliferation activity and the early apoptosis of Ruditapes philippinarum peptides in vitro were detected by MTT,inverted microscope and AO/EB double staining respectively.[Result] Determined by MTT method,different concentration of peptides to DU-145 cells had obvious growth inhibition.Cell apoptosis morphological feature was observed under AO/EB double staining and inverted microscope.[Conclusion] Ruditapes philippinarum under 3 kD enzyme solution of molecular weight with inhibition of DU-145 cells growth,induce prostate cancer cells apoptosis,and a concentration and time dependence.
【Fund】: 浙江省自然科学基金(LY12C20008)
【CateGory Index】: S917.4
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Chinese Journal Full-text Database 6 Hits
1 ZENG Ming-yong,CUI Hai-ying,LI Ba-fang(Ocean University of China, Qingdao 266003,China);Progress in studies of marine bioactive peptides and their bioactivities[J];Chinese Journal of Marine Drugs;2005-01
2 FAN Xiu-ping,WU Hong-mian,WANG Ya-nan,HU Xue-qiong,YE Qing-jun (School of Food Science and Technology, Guangdong Ocean University, Zhanjiang 524006, China);Immune Activity of Glycosaminoglycan from Ruditapes philippinarum[J];Food Science;2008-04
3 WANG Dao1,2,ZHU Cui-feng1.(1.Department of Nurition,Peking University Shenzhen Hospital,Shenzhen 518036,China;2.Shantou Medical College,Shantou 515041,China);The Development of Biological Activity Research of Marine Biological Activity Peptide[J];Medical Recapitulate;2011-05
4 HUANG Fang-fang,YANG Yong-fang,DING Guo-fang School of Food Science and Pharmacy,Zhejiang Ocean University,Zhoushan 316004,China;Advances in the study of antitumor activities of the marine mollusks extracts[J];Journal of China Pharmaceutical University;2009-03
5 YANG Yong-fang,YANG Zui-su,DING Guo-fang,YU Di,HUANG Fang-fang(School of Food Science and Pharmacy of Zhejiang Ocean University,Zhoushan 316004,Zhejiang,China);Study of the Isolation and Purification of Antioxidative Peptides from Short Necked Clam,Ruditapes Philippinarum[J];Chinese Archives of Traditional Chinese Medicine;2011-05
6 YANG Zuisu1,FENG Bo2,XU Changfen3(1.Medical School,Zhejiang Ocean University,Zhoushan 316004 Zhejiang,China;2.Huai'an Maternal and Child Health Hospital,Huai'an 210005 Jiangsu,China;3.Department of Histology and Embryology,Nanjing Medical University,Nanjing 210029,China);Effect of 4'-Methery-scutellarein on c-myc Expression in Human Choriocarcinoma JAR Cells[J];Traditional Chinese Drug Research and Clinical Pharmacology;2011-05
Chinese Journal Full-text Database 10 Hits
1 LIAN Lu1,CONG Feng-song2,CAI Dong-lian1,LIN Ning1,QU Dan1,ZHENG Hui1,WANG Jie1(1、Department of Clinical Nutrition,Changhai Hospital,Second Military Medical University,Shanghai 200433;2、College of Life Science And Technology,Shanghai Jiao Tong University,Shanghai 200240,China);Effect of Deuterium-Depleted Water on Immunomodulation in Mice[J];Amino Acids & Biotic Resources;2010-03
2 YANG Chang-qing1,CAI Mu-yi2,PAN Xing-chang2,GU Rui-zeng2,HU Wen1(1.Clinical Nutrition Department of West China Hospital of Sichuan University,Chengdu,Sichuan 610041,China;2.China National Research Institute of Food & Fermentation Instruries,Beijing 100027,China);Application of marine collagen peptide in dialysis patients[J];Journal of Chengdu Medical College;2011-04
3 LI Li et al ( Zhejiang Provincial Key Engineering Technology Research Center of Marine Biomedical Products,School of Food Science and Pharmacy,Zhejiang Ocean University,Zhoushan,Zhejiang 316004);Study on the Anticancer Activity of the Ruditapes philippinarum Hydrolysate on the Lung Cancer H1299 cells[J];Journal of Anhui Agricultural Sciences;2013-14
4 FANG Lian-hua,ZHU Xiao-ming,ZHANG Ran,HU Juan-juan,DU Guan-hua(Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China);Evaluation of antihypertensive effects of salmon protein hydrolysates[J];Chinese Journal of Marine Drugs;2008-02
5 XING Xiao-xu,ZHAO Xia*,LI Da-jing,YU Guang-li,YIN Xiu-hong(Key Laboratory of Marine Drugs,Ministry of Education,Shandong Provincial Key laboratory of Glycoscience and Glycoengineering,School of Medicine and Pharmacy, Ocean University of China,Qingdao 266003,China);Extraction,separation and structural characterization of polysaccharides from Neverita didyma[J];Chinese Journal of Marine Drugs;2013-04
6 YU Di1,YANG Yong-fang1,WANG jia-bin2,et al(1.School of Food and Pharmacy of Zhejiang Ocean University,Zhoushan 316004; 2.Hailisheng Pharmaceutical Co Ltd,Zhoushan 316021,China);Study of Glycoprotein Extracted and Purified From Ruditapes philippinarum Inhibits the Growth of Tumor Cell in Vitro[J];Journal of Zhejiang Ocean University(Natural Science);2011-04
7 YU Di,XU Xin-jian,YANG Zui-su,et al(Food and Pharmacy & Medical School of Zhejiang Ocean University,Zhoushan 316004,China);Study on the Antioxidant Activities of Enzymatic Hydrolysate From Ruditapes philippinarum[J];Journal of Zhejiang Ocean University(Natural Science);2011-06
8 ZHANG Yan-kun,ZHANG Dong-xiang(Institute ofHygiene and Environmental Medicine,Academyof Military Medical Sciences,Tianjin300050,China);Progress in study on antitumor effect and mechanism of bioactive peptides[J];Chinese Journal of Biochemical Pharmaceutics;2006-06
9 ZHANG Mian-song1,3,YUAN Wen-peng2,3,WANG Xiao-jun2,3,MENG Xiu-mei2,3,XIA Xue-kui1,3,LIU Chang-heng2,3,(1.Biotechnology Center of Shandong Academy of Sciences,Jinan 250014,China;2.Biology Institute of Shandong Academy of Sciences,Jinan 250014,China;3.Platform of Marine Food Biotechnology,Shandong Academy of Sciences,Jinan 250014,China);Study on the hydrolysis conditions of jellyfish[J];Science and Technology of Food Industry;2010-02
10 HU Zhi-he~(1,2) WANG Chang-lu~1 (1.College of Food Engineering and Biotechnology,Tianjin University of Science and Technology,Tianjin 300222,China; 2.Tianjin Key Laboratory of Food Biotechnology,College of Biotechnology and Food Science,Tianjin University of Commerce, Tianjin 300134,China);Enzyme Engineering Application Review on Protein Product Economic Value Promotion[J];Food Science;2007-05
China Proceedings of conference Full-text Database 3 Hits
1 FAN Xiu-ping,WANG Rui-fang,WU Hong-mian,WANG Ya-nan,HU Xue-qiong,LEI Xiao-lin (School of Food Science and Technology,Guangdong Ocean University,Zhanjiang 524006,China);Structural Characteristics and Immunomodulatory Activity of Glycosaminoglycan RG-1 from Ruditapes philippinarum[A];[C];2010
2 Xinrong Pei,Ruiyue Yang,Zhaofeng Zhang,Yajun Xu,Xiaolong Han,Junbo Wang,Yong Li.Department of Food and Nutritional Hygiene,School of Public Health,Beijing University, Beijing 100083,China;Effect of Marine collagen peptide on the delay of skin aging[A];[C];2008
3 Wang Junbo,Xie Ying~*,Pei Xinrong,Yang Ruiyue,Zhang Zhaofeng,Li Yong (Department of Nutrition and Food Hygiene,School of Public Health,Peking University Health Science Center,Beijing 100083,China,*.Department of Pharmacy,School of Pharmaceutical Science,Peking University Health Science Center,Beijing 100083,China);The lipid-lowering and antioxidative effects of Marine collagen peptides[A];[C];2008
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 SHI Xiao dong CHEN Xiu lan HE Hai lun ZHANG Yu zhong (state Key Lab of Microbial Technology,institute of Microbiology, Shandong Iniversity,Kinan 250100);Outline and Perspective of Research and Development of Bioactive Peptides from Marine Protein Enzymatic Hydrolysate[J];Amino Acids & Biotic Resources;2000-04
2 XING Cheng-ming,SHANG Yan-chang,YUAN Xiao-ling, et al (Department of Neurology,Tongji Hospital, Tongji Medical School of Huazhong University of Science and Technology,Wuhan 430030, China);EFFECTS OF RUDITAPES PHILIPPINARUM ON THE PREVENTION AND TREATMENT OF ATHEROSCLEROSIS IN RABBITS[J];Acta Acadimae Qingdao Umvesitatis;2005-02
3 LIN Hou-Wen , GAO Yong, LIU Gao-Lin , WANG Jie-Jun, ZHANG Chun( Department of Pharmacy, Changzheng Hospital t Second Military Medical University, Shanghai 200003, China; Department of Oncology, Changzheng Hospital);Studies on in vitro antitumor activities of a new sterol HEO from sea hare[J];Academic Journal of Second Military Medical University;2004-05
4 YAO Ying,WEI Jiang-zhou,WANG Jun,ZHANG Jian-peng,LIU Jun-hua,FENG Wei-hua *,JIAO Bing-hua *(Department of Biochemistry and Molecular Biology,College of Basic Medical Sciences,Second Military Medical University,Shanghai 200433,China);Extraction of Mytilus coruscus polysaccharides and study on their immunoactivities[J];Academic Journal of Second Military Medical University;2005-08
5 XU Hong-li~(1),GUO Ting-ting~(2),GUO Yi-feng~(1),ZHANG Jian-peng~(1),FENG Wei-hua~(1*),JIAO Bing-hua~(1*)(1.Department of Biochemistry and Molecular Biology,College of Basic Medical Sciences,Second Military Medical University,Shanghai 200433,China;2.Central Laboratory,Aqua-life Science and Technology College,Shanghai Fisheries University,Shanghai 200090);Isolation and purification of water-soluble polysaccharide MP-Ⅰ from Mytilus coruscus and study on its in vitro anti-tumor activity[J];Academic Journal of Second Military Medical University;2006-09
6 XU Jun fa HU ANG Di nan,LU Shi jing,et al (Department of Laboratory Medicine,Guangdong Medical College,Zhanjiang 524023,China) [;Zymosan enhances the immune function of mouse peritoneal macrophages in vitro[J];Journal of Guangdong Medical College;2003-03
7 ZHANG Li, LIU Wan-Shun, HAN Bao-Qin, LIU Wen, LIU Bing (College of Marine Life Sciences and Technology,Ocean University of China,Qingdao,266003);PRELIMINARY STUDY ON THE ANTITUMOR ACTIVITIES OF PROTEOGLYCAN FROM RUDITAPES PHILIPPINARUM[J];Oceanologia Et Limnologia Sinica;2007-01
8 Wang Jingfeng,Zhang Jun,Li Lide,et al (Qingdao Ocean University,Qingdao 266003);EFFECTS OF EXTRACT FROM VENERUPIS VARIEGATA (EVV) ON IMMUNE FUNCTION OF MICE[J];Chinese Journal of Marine Drugs;1998-02
10 LIN Hou wen, ZHANG Chun, YI Yang hua, et al (Department of Pharmacy, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai 200003);Studies on antineoplastic constituents from chinese marine mollusc sea hare(Ⅰ)[J];Chinese Journal of Marine Drugs;2001-03
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