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《Anhui Medical Journal》 2005-02
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Effect of Helicobacter pylori infection on serum nitric oxide and motor function of esophagus

Wu Zhengxiang, Zhang Mingli, Xie Li, et al Department of Gastroenterology, Anhui Provincial Hospital, Hefei 230001  
Objective To explore the effect and possible mechanism of Helicobacter pylori(Hp) infection on serum Nitric oxide(NO) and motor function of esophagus.Methods Hp infection,serum NO and motor function of esophagus were determined in 92 patients with chronic gastritis.Results The serum NO of 54 cases with Hp infection was significantly higher(97.00±113.35) than 32 without(49.82±26.50).There was no significant different in UESP,LESP and esophageal body peristalsis.There was a significant improvement in NO(136.18±182.78 vs. 43.10±17.95, P=0.037) and LESP (14.10±8.16 mmHg vs. 18.71±8.22 mmHg, P=0.001), but not in UESP(35.87±13.56 mmHg vs 38.63±16.93 mmHg, P=0.412) and esophageal body peristalsis(5.32±3.79 vs 6.21±3.43, P=0.112) before and after Hp eradication in 19 patients.Conclusion Hp infection may be result in increasing the content of serum NO. But the effect on esophagus motor function was not increased content of NO. There was a significant improvement in LESP after Hp eradiation.
【CateGory Index】: R57
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