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Effect of salvia miltiorrhizae on water content in rats during early postburn stage

Liu Yuling , Chen Xiaying , Chen XuLin, et al.Department of Experimental Surgery Laboratory of the First Clinical College in Anhui Medical University , Hefei , 230032  
Objective To investigate the dynamical change of water content in liver during early stage postburn , and to study the effect of salvia miltiorrhizae(SM) on them. Methods Eighty-eight Wistar rats were randomly divided into three groups : normal control group (group A) , burn group (group B) , and burn plus SM group (group C) . Rats of group B and C received a 30% III-degree burn and were resuscitated immediately with lactated Ringer’s solution (120 ml/kg/). Additionally , rats of group C received SM at a dose of 3 ml/kg . Water content in liver was measured at 3 , 6 , 12 , 24 , 48 h after burn.Results (1) In group B , water content in liver increased remarkably at 6 hours after burn and reached the top at 48 hours postburn , the change tendency of water content in liver in group C was similar to that in group B . In comparison with group B , in group C was much lower.Conclusion (1) . water content in liver increased remarkably in rats during early postburn stage.(2) SM can reduce water content in liver and has a protective effect on liver injury of scalded rats during early stage.
【CateGory Index】: R285
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