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《Anhui Medical Journal》 2009-07
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Quantitative expression of interleukin-23 receptor gene in ankylosing spondylitis patients

Fan Xiaoyun;Shen Nan;Wang Yuan Department of Rheumatology,the Affiliated Hospital of Bengbu Medical College,Bengbu 233004  
Objective To investigate the gene expression of Interleukin-23 Receptor(IL-23R)in ankylosing spondylitis atients.Methods Total mRNA of peripheral blood white cells were obtained from 61 AS patients(satisfying the modified New York criteria,1984)and 40 matched healthy subjects and their cDNA were synthesized.Disease activity was assessed by the criterion of the Bath ankylosing spondylitisdisease activity index(BASDAI)and defined into two levels:inactivity(average score ≤4)and activity(average score≥5).All the patients received combined therapy of MTX+SASP+NASIDs.and none of them have been treated with biologics.Semi-Quantitative real-time PCR was used to determine the expression of IL-23R.Results The expression of IL-23R in AS patients were significant higher vs healthy controls(P=0.0004).Compared with inactivity patients(n =35),the expression of IL-23R in activity patients(n=26)shows no significant difference though it shows increase tendency(P=0.2224).Conclusion These results suggest that the expression of IL-23R is up-regulated in ankylosing spondylitis and may contribute to AS pathogenesis and prognosis.IL-23R may participate these immune disorders through it's essential function in IL-23/Th17 axis which remains much more details to be further detected.Our findings suggest that the IL-23 pathway may also be a promising target for treatment of AS.
【CateGory Index】: R593.23
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