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《Anhui Medical Journal》 2011-01
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Comparison of different ventilation modes on newborn rabbits with severe meconium aspiration syndrome

Li Na,Zhou Haiyan,Wu Rong Department of Pediatrics,Chuzhou Clinical College,Anhui Medical University,Chuzhou 239000,China  
Objective To observe the changes of lung dynamic compliance(Cydn),mean airway pressure(MAP),minute ventilation(MV),tidal volume(VT),respiratory rate(RR) and heart rate(HR) in the newborn rabbits with severe meconium aspiration syndrome.Methods Eighteen newborn rabbits were divided randomly into 3 groups of Assistor Control Mandatory Ventilation(A/C),Control Mandatory Ventilation(CMV) and Synchronized intermittent Mandatory Ventilation(SIMV).Set the parameters in order to maintain normal tidal volume range(4~10 ml/kg) and normal oxygen saturation(85% or more).The pulmonary dynamic compliance(Cydn),mean airway pressure(MAP),minute ventilation(MV),tidal volume(VT),respiratory rate(RR) and heart rate(HR) were observed.Results In the three modes,there were no statistically significant differences in HR(F=0.649,P=0.593) and VT(F=2.548,P=0.085).But there were statistically significant differences in RR(F=240.057P=0.000),Cydn(F=311.309P=0.000),MAP(F=127.354P=0.000) and MV(F=25.136P=0.000).Among them,the mean airway pressure of A/C group was the highest and the lung dynamic compliance of SIMV group was the highest.Conclusion The above ventilator parameters have certain regularity,which can be inferred that SIMV mode can be used as the preferred mode of treatment of severe MAS.
【CateGory Index】: R722.1
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【Citations】
Chinese Journal Full-text Database 2 Hits
1 Zhou Haiyan,Wu Rong Department of Pediatrics,Chuzhou Clinical College of Anhui Medical University,Chuzhou 239000,China;Model of severe meconium aspiration in newly-born rabbits[J];Anhui Medical Journal;2010-09
2 LI Yun, WU Rong. Pediatrics Depannlent in ChuZhou Clinical InstitIlte of Anhui Medical University, ChuZhou 239000, China;Observation of proportional assist ventilation application in 6 cases of neonatal meconium aspiration syndrome[J];China Healthcare Frontiers;2009-24
【Co-citations】
Chinese Journal Full-text Database 3 Hits
1 Lin Na,Zhou Haiyan Wu Rong Department of Pediatrics,Chuzhou Clinical College,Anhui Medical University,Chuzhou 239000,China;Observation of the lung pathology of meconium aspirated newborn rabbits treated by dexamethasone[J];Anhui Medical Journal;2010-10
2 DONG Ke-jiang1,LI Na2,ZHOU Hai-yan2,WU Rong2. ( 1. Staff Room of Physiology,Health School of Chuzhou, Chuzhou 239000,China; 2. Department of Neonatology,Huaian Hospital for Maternal and Child Health Care,Huaian 223002,China);Observation of the Physiological Parameters in Newborn Meconium Aspirated Rabbits[J];Medical Recapitulate;2010-21
3 ZHAN Feng,WU Rong,ZHOU Hai-yan,LI Na.(Department of Pediatrics,Chuzhou Clinical College,Anhui Medical University,Chuzhou 239000,China);Change in Pathology of Lung Tissue in Meconium-injured Newborn Rabbits Treated with Aminophylline[J];Medical Recapitulate;2010-23
【Secondary Citations】
Chinese Journal Full-text Database 2 Hits
1 Wu Rong,Zhou Hai-yan(Pediatrics Department in ChuZhou Clinical Institute of Anhui Medical University,239000);Observation of proportional assist ventilation application in 15 cases of neonatal mechanical ventilation[J];China Healthcare Frontiers;2009-05
2 DU Yue, CAI Xu xu, WU Yu bin, et al. Department of Pediatrics, The Second Affiliated Hospital of China Medical University, Shenyang 110004,China;Research on the changes of expression of MMP 2 and TIMP 2 in the neonatal rats lung tissue caused by LPS[J];Chinese Journal of Perinatal Medicine;2004-06
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