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《Anhui Medical and Pharmaceutical Journal》 2003-04
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Quantitation of local 5-Fu concent in the patients with rectal cancer performed 5-Fu SRI local chemotherapy

WAN Sheng Yun,LIU Yi, ZHANG Jun Shun (Dept of Surgery,Afficiated Hospital,Anhui Medical Univesty,Hefei 230022)  
AIM In order to evaluate the effect of a neoadjuvantchemotherapy with 5 Fluorouracil sustained release for implant(5 Fu SRI)injected in rectal submucosa in the patients with rectal cancer.The effect of this treatment was judged by 5 Fu concentration in blood and tissue. METHODS 13 patients with rectal cancer underwent the treatment of submucosal multiple 5 Fu SRI with the simple dose of 500 mg before 72 hours of operation.The level of 5 Fu in peripheral veins,inferior mesenteric veins and in the tissues of tumor and para tumor was studied. 5 Fu was detected by high performance liquid chromatography (HPLC). The program of SPSS(10) was used.Data were presented as means±standard deviation(SD). RESULTS The concentration of 5 Fu in peripleral veins, inferior mesenteric veins,tumor tissues and pera tumor tissues at 72 h were (0 219±0 162),(0 418±0 261),(1 478±1 333) and (0 646±0 600) mg·kg -1 respectively.NO side effect was found in all patients.CONCLUSION The treatment of rectal submucosal multiple implant of 5 FuSRl presents a significant local high 5 Fu concentration advantage and reasonability in preventing post operative recurrence,metastasis of rectal cancer.
【Fund】: 安徽省科技厅重点项目
【CateGory Index】: R735.37
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