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Effect of astragalus polysaccharide on immunologic function in mice

Xu Du Juan, Chen Ming Zhu (Institute of Clinical Pharmacology , Anhui Medical University ,Hefei 230032)  
AIM To study the immunomodulatory effect of Astragalus polysaccharide. METHODS By using 3H TdR incorporation methods, the proliferation of splenocytes was tested. TNF αand IFN γwould be assayed by radioimmunoreagent kit and ELISA kit. RESULTS APS could enhance the splenocyte proliferation induced by ConA or LPS. APS increased TNF α production of peritoneal macrophages and IFN γproduction of splenocytes. CONCLUSION APS in vitro possessed a immunopotentiating activity on main immune functions of T,B lymophocytes and macrophages.
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