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《Anhui Medical and Pharmaceutical Journal》 2004-02
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Inhibitory effects of paeonol on the proliferation of four tumor cell lines

SUN Guo Ping,WANG Hua 1,SHEN Yu Xian 1,XU Shu Yun 1 ( Dept of Oncology,The Frist Affiliated Hospital of Anhui Medical University,Hefei 230022; 1Instiute of Clinical Pharmacology,Anhui Medical University,Hefei 230032)  
AIM To study the infuence of paeonol on the proliferation of tumor cell lines in vitro. METHODS The inhibitory effect of paeonol on tumor cells proliferation was assayed by MTT dye reduction. RESULTS PAE at concentrations of 7 81~250 mg·L -1 inhibited proliferation of four tumor cell lines in vitro (human erythroleukemic cell line K 562 , breast cancer gene cell line T 6~17 , hepatocarcinoma cell line Bel 7404 and cervical cancer cell line HeLa) with different IC 50 (30 83, 13 44, 69 89 and 93 91 mg·L -1 , respectively). It was observed that higher concentration of PAE, more inhibitory effect, suggesting obvious concentration effect relationship of PAE. The inhibitory effects were augmented with the prolongation of culture time (24, 48, 72 to 96 h), suggesting time effect relationship of PAE. CONCULSION Paeonol may inhibit the proliferation of different types of tumor cell lines in vitro.
【Fund】: 安徽省自然科学基金资助课题 (No 0 0 0 4 4 4 1 4 ) ;; 安徽省教育厅自然科学基金重点项目 (No 2 0 0 3Kj0 37zd)
【CateGory Index】: R73-36
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