Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Anhui Medical and Pharmaceutical Journal》 2005-02
Add to Favorite Get Latest Update

Measurement of nitric oxide and its inducible synthase in sera and joint fluids of patients with osteoarthritis

LI Mei-rong,WANG Mei-mei (Dept of Rheumatology,Xuzhou Center Hospital, Jiangsu Province, Xuzhou 221009,China)  
Aim To investigate the relationship between the levels of nitric oxide(NO) and its inducible synthase(iNOS) in sera and joint fluids of patients with osteoarthritis (OA) and the activity of the disease.Methods The levels of NO, iNOS, erythrocyte sedimentation rate (ESR) and C reactive protein (CRP) in sera and joint fluids of 30 patients with mild, moderate or severe OA respectively and 24 healthy volunteers were measured.Results ① The levels of NO and iNOS in sera and joint fluids of patients with moderate and severe OA were higher than that of normal controls(P0.01).② In comparison with that of normal controls,the levels of NO and iNOS in joint fluids of all patients with OA increased significantly (P0.001).③ The levels of NO and iNOS in joint fluids of patients with severe OA correlated positively with that in sera(r=0.589, P0.01).④ The levels of NO and iNOS in joint fluids of patients with moderate and severe OA correlated positively with the levels of serum ESR and CRP(r=0.428, P0.05).Conclusion iNOS and iNOS-derived NO may mediate the pathogenesis and development of OA.
【CateGory Index】: R684
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 5 Hits
1 WEI You-xiu,WEI Zhuo,LIU Ping,ZHOU Wei,SUN Wen-xiao(Department of Orthopedic,Affiliated Liyuan Hospital of Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430077,China);Experimental study on the repair of articular cartilage defects and prevention on osteoarthritis by intra-articular injection of IGF-1、TGF-β1[J];Chinese Journal of Clinical Healthcare;2010-03
2 Liang Peng-zhan1, Jiang Jian-ming1, Liu Chuan-fang1, Sun Wei2, Yu Lei3, Qiu Xiao-zhong3(1Department of Orthopaedics and Spine Surgery,Nanfang Hospital,Southern Medical University, Guangzhou 510515, Guangdong Province, China;2Department of Spine Surgery, Shenzhen Second People's Hospital, Shenzhen 518035, Guangdong Province, China;3Department of Anatomy, Southern Medical University,Key Laboratory of Tissue Constructionand Detection of Guangdong Province,Guangzhou 510515, Guangdong Province, China);Effects of nitricoxide synthase inhibitor on interleukin-1 beta-induced chondrocyte proliferation and matrix metalloproteinase expression[J];Journal of Clinical Rehabilitative Tissue Engineering Research;2008-15
3 JIANG Jian-ming,LIANG Peng-zhan,LIU Chuan-fang,SUN Wei Department of Spine Surgery, Southern Hospital,Southern Medical University,Guangzhou 510515 China;Effect of transforming growth factor-beta on interleukin 1-beta-induced nitric oxide expression in human osteoarthritis chondrocytes[J];Chinese Bone and Joint Surgery;2008-01
4 QIN Meng 1 WANG Heming 1 LOU Yuqian 2 1 Fujian University of Traditional Chinese Medicine 2Henan Hospital of Rheumatism;Effect of Gubishu Tablet on Pathomorphology and Free Radical of Experimental Knee Osteoarthritis[J];Chinese Journal of Traditional Medical Traumatology & Orthopedics;2011-03
5 YANG Lin,GUO Ai. Beijing Friendship Hospital,Capital University of Medical Science,Beijing 100050,China;Role of NO in the development of osteoarthritis[J];Orthopedic Journal of China;2009-07
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 ZHANG Xiao-Ling, Yu Chang-Long △ (Institute of Sports Medicine, Peking University Third Hospital,Beijing 100083,China);Current status and prospects of gene therapy approaches for osteoarthritis[J];Journal of Beijing Medical University;2002-05
2 TIAN Hua 1△ , Carrie FANG 2, Paul E. DICESARE 2 (1. Department of Orthopaedics, Peking University Third Hospital, Beijing 100083,China;2. Institute of Orthopaedic Surgery, NYU-Hospital for Joint Diseases,USA);Effects of bone morphogenetic protein-2 on cartilage oligomeric matrix protein expression in chondrocytes[J];Journal of Beijing Medical University;2003-03
3 ;Advanced Research on Cartilage Repair and Reconstruction[J];China Comtemporary Medicine;2001-01
4 ZHU Dao-chen, ZHANG Ling-hua, WANG Yun-ji (Coll. of Bio. & Food Technol., Dalian Inst. of Light Ind., Dalian 116034, China);Separating and screening of the anti-inflammatory part of lumbricus animal[J];Journal of Dalian Institute of Light Industry;2004-01
5 XIE Zhao, XU Jian-zhong, ZHOU Qiang,XIE Si-jie (Department of Orthopedics, Southwest Hospital, Third Military Medical University, Chongqing 400038,China);Apoptosis of tissue engineered articular chondrocytes constructed by centrifuge tube[J];Acta Academiae Medicine Militaris Tertiae;2002-05
6 PENG Dan ,SUN Caijiang,ZHOU Jiangnan. Department of Orthopaedics,Second Affiliated Hospital,Hunan Medical University,Changsha 410011,China;The regulation effect of NO in the apoptosis of chondrocytes in experimental OA[J];CHINESE JOURNAL OF RHEUMATOLOGY;2000-04
7 GUAN Jianlong ,SHI Guiying,HAN Xinghai,et al. Department of Rheumatology,Changhai Hospital,Second Military Medical University,Shanghai 200433,China.;Matrix metalloproteinase (MMP)-2 and-9 in serum and synovial fluid in patients with osteoarthritis[J];Chinese Journal of Rheumatology;2001-02
8 YANG Chunhua,HUANG Feng.General Hospital of PLA,Beijing 100853,China.;Detection and significance of urokinase-type plasminogen activator and its receptor in synovial fluid and plasma in rheumatoid arthritis[J];Chinese Journal of Rheumatology;2001-03
9 WU Hongbin ,DU Jingyuan,HU Yong,LIU Weigang,FU Gang,ZHANG Jinghui. Department of Orthopedics Union Hospital,Tongji Medical College of Huazhong Science and Technology University,Wuhan 430022,China;Expression of MMP-1 MMP-13 and TlMP-1 mRNA in cartilage and synovium of experimentally induced rabbit ACLT osteoarthritis[J];Chinese Journal of Rheumatology;2002-03
10 WANG Yi,XING Guo-sheng,YU Shun-lu,LI De-da,ZHANG Kai,HUANG Jin,SHENG Li,WANG Xue-min,LI Shi-min.Biochemistry Lab,Research Institute of Orthopedics,Tianjin Hospital,Tianjin 300211,China;Expression of metalloproteinases and tissue type inhibitors of metalloproteinases in chondrocyte of rabbit articular cartilage and effects of selected drugs in vitro[J];Chinese Journal of Rheumatology;2003-12
【Secondary References】
Chinese Journal Full-text Database 4 Hits
1 ZHU Junsong1,WU Xuping2,ZHANG Tianmin2(1.Grade 2008 postgraduate student,Hubei University of Chinese Medicine,Wuhan 430061,Hubei,China;2.Hubei University of Chinese Medicine,Wuhan 430061,Hubei,China);Acupotomy upon Five Finger Locating with Overall Loosening on SOD,NO and TNF-α in Knee Osteoarthritis Patients[J];Journal of Hubei University of Chinese Medicine;2011-02
2 Mu-Dan He~(1,2),Xiao-Ping Wang~(1*),Tong-Sheng Chen~2 (1 Department of Anesthesiology,First Clinical Medical College,Jinan University,Guangzhou 510632,China;2 MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science,South China Normal University,Guangzhou 510631,China);The Molecular Mechanism of IL-1β-induced Articular Chondrocytes Apoptosis[J];Chinese Journal of Cell Biology;2011-01
3 ;曲安奈德冲洗液在膝骨性关节炎行关节镜手术中的应用[J];Modern Clinical Nursing;2010-11
4 QIN Meng 1 WANG Heming 1 LOU Yuqian 2 1 Fujian University of Traditional Chinese Medicine 2Henan Hospital of Rheumatism;Effect of Gubishu Tablet on Pathomorphology and Free Radical of Experimental Knee Osteoarthritis[J];Chinese Journal of Traditional Medical Traumatology & Orthopedics;2011-03
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved