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《Anhui Medical and Pharmaceutical Journal》 2006-01
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Proliferation inhibition of TGP on SMMC-7721 Cell in vitro

WANG Shi-hong~(1,2),WEI Wei~(1),XU Du-juan~(1),XU Shu-ping~(1),CUI Ying~(2)(1.Institute of Clinical Pharmacology,Anhui Medical University;Anhui Key Laboratory of Antiinflammatory and Immunopharmacology;Anhui Provincial Key Laboratory of R&D of Chinese Medicine,Hefei 230032;2.He'nan College of TCM,Zhengzhou 450008)  
Aim To study the proliferation inhibition of different concentrations of total glucosides of paeony(TGP) on human hepatoma cell SMMC-7721. Methods The proliferation inhibitory effect of TGP on tumor cells was assayed by MTT method.The morphologic changes of the human hepatoma cell SMMC-7721 was observed by staining with acridine orange(AO)fluorescent dyes.Results TGP(0.5~2.5 g·L~(-1)) had inhibitory effect on the proliferation of SMMC-7721 with the concentration-dependence.AO dying showed TGP induced typical chromatin condensation in SMMC-7721 cells.Conclusion TGP can inhibit the proliferation of SMMC-7721 cells in vitro and induce its apoptosis.
【CateGory Index】: R735.7
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