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《Anhui Medical and Pharmaceutical Journal》 2006-05
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Effect of compound astragalus extract on TNFα、NO and IL-1 secreted by rat peritoneal macrophages induced by lipopolysaccharide

LU Jing-tao,CHEN Min-zhu(Institute of Clinical Pharmacology,Anhui Medical University,Hefei 230032)  
Aim To study effect of compound astragalus extract(CAE)on TNFα,IL-1 and NO secreted by normal rat peritoneal macrophages(PM_(Φ)).Methods Rat peritoneal macrophages was stimulated with 10 mg·L~(-1 )LPS in vitro.TNFα was measured by assay of cytotoxicity against L929 cells ,The concentration of NO was determined by Griess assay,activity of IL-1 was assayed by \TdR incorporation assay.Results CAE could markedly inhibit production of TNFα,IL-1 and NO from normal rats PM_(Φs) induced by LPS.Conclusion Inhibiting directly secretion of TNFα,IL-1 and NO produced by PM_Φs might be one of the mechanisms of hepatoprotective effect of CAE.
【CateGory Index】: R285
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【References】
Chinese Journal Full-text Database 7 Hits
1 LI Wei-zu,LI Wei-ping,YIN Yan-yan,ZHANG Yun-ling(Dept of Pharmacology,Anhui Medical University,Hefei 230032);Protective effects of AST and ASI on glucocorticoid-induced mouse memory impairment and its mechanism[J];Anhui Medical and Pharmaceutical Journal;2008-07
2 Shi Zigang1, Ren Shicun1,Xu Jin2(1.Qinghai University Medical College;2.Nursing college of Zhongshan university);EXPERIMENTAL STUDY ON QIZHI CAPSULE PROTECTION TO ACUTE HEPATIC INJURY INDUCED BY CCL_4 IN MICE[J];Journal of Qinghai Medical College;2008-01
3 WANG Fengyun1,TANG Xudong2,LIU Yanling3,JIN Long1,GE Zhengyan1,BIAN Liqun2 1.Department of Laboratory Center;2.Department of Gastroenterology;3.Department of Hepatology,Xiyuan Hospital of China Academy of TCM,Beijing 100091,China;Effects of Traditional Chinese Medicine-Rongganheji on mice with liver injury induced by concanavalin A (ConA)[J];Chinese Journal of Gastroenterology and Hepatology;2008-06
4 Yuan Yuan Mei Sun Department of Pediatrics,Shengjing Affiliated Hospital of China Medical University,Shenyang 110004,Liaoning Province,China;Mechanism of impact of Astragalus mongholicus polysaccharides on lipopolysaccharide-induced damage in intestinal epithelial cells[J];World Chinese Journal of Digestology;2008-01
5 LU Jing-tao,YANG Yan,WEI Wei,et al (Institute of Clinical Pharmacology,Anhui Medical University,Hefei 230032,China);Protective Effects of Compound Astragalus Extract on Chemical and Immunalogical Liver Injury in Mice[J];Chinese Journal of Information on Traditional Chinese Medicine;2008-01
6 YUAN Yuan1,3,QI Yong-jun2,XU Ling-fen1,SUN Mei1.1.Department of Pediatrics,The Shengjing Affiliated Hospital of China Medical University,Shenyang 110004,Liaoning,China;2.Department of Pediatrics,The Longnan Hospital of Daqing,Daqing 163453,Heilongjiang,China;3.Department of Pediatrics,The PLA 211th Hospital,Harbin 150086,Heilongjiang,China;Effect of Astragalus mongholicus polysaccharides(黄芪多糖) on intercellular adhesion molecule-1 secreted by in vitro intestinal epithelial cell induced by lipopolysaccharide[J];Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care;2008-02
7 LIU Qian,WANG Dongqi,LEI Xinjun,et al.(Medical College of Xi'an Jiaotong University,Xi'an 710061);Effects of Naoxintong Capsule on Cell Vitality and Inflammatory Reaction of THP-1 Macrophages Induced by Oxidized Low Density Lipoprotein[J];Journal of Traditional Chinese Medicine;2009-10
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 HU Bin-jie et al (Chemical Engineering Institute,Kaifeng University,Kaifeng,Henan 475004);Best Fermentation Condition of Flainmulina velutipes in Submerged Culture Obtaining Polysaccharide[J];Journal of Anhui Agricultural Sciences;2007-10
2 ZHANG Yu-jun et al (Staff Room of Biochemistry,Shandong Wanjie Medical College,Zibo,Shandong 255213);Research Progress on the Medicinal Components in Lentinus edodes and Its Antitumor Effect[J];Journal of Anhui Agricultural Sciences;2008-31
3 LI Wei-zu,LI Wei-ping,YIN Yan-yan,ZHANG Yun-ling(Dept of Pharmacology,Anhui Medical University,Hefei 230032);Protective effects of AST and ASI on glucocorticoid-induced mouse memory impairment and its mechanism[J];Anhui Medical and Pharmaceutical Journal;2008-07
4 SHAO Fu-rong,WEI Wei,LIU Hao,SUN Wu-yi,LI Xiang(Institute of Clinical Pharmacology of Anhui Medical University, Anhui Hefei 230032,China);Comparison of Protective Effect of Shaoqiduogan Extracted by Different Methods on Immunological Liver Injury in Mice[J];Journal of Anhui Traditional Chinese Medical College;2007-05
5 LU Yan qi, HE Xue li (College of Life Science,Hebei University, Baoding 071002,China);The Study of Chemical Composition and Pharmacological Function on Astragalus L.[J];Journal of Baoding Teachers College;2004-04
6 Tang Fenfang;Jin Zonglian;Wang Lei;Zhang Wenqing;Zhao Hong(College of Sciences and Humanites of BUU,100083)Li Jingqi(Beijing Research Institute for Nutritional Resources,100054)[;Evaluation of the Effect of Zymosis Juice of Lentinus Edodes on the Antiaging And Immunity of Mice[J];JOURNAL OF BEIJING UNION UNIVERSITY;1994-01
7 CUI Ming-ji 1,XU Xue-ming 1,ZHANG Rui 2 (1 Department of Nephrogy,First Hospital,Jilin University,Changchun 130021 China; 2\ The People′s Hospital of Jilin province) [;Change of neuropeptide Y in plasma in chronic renal failure patients and the effects of Astragalus on it[J];;2001-02
8 ZHAO Li juan, LI Hong, YANG Shi jie(Dept.of Pharmacology, School of Basic Medical Sciences,Jilin University,Changchun 130021,China);Protective Effect of Membranous Milkvetch Root Injection from Acute Hepatic Injury in Mouse Induced with D-GalN[J];Journal of Jilin University of (Medicine Edition);2003-03
9 TU Peng-Fei △, GUO Hong-Zhu,GUO De-An [Peking University Modern Research Center for Traditional Chinese Medicine (P KUMRCTCM), Beijing 100083,China];Researches on active constituents of natural and traditional medicine and develo pment of new drugs[J];Journal of Beijing Medical University;2002-05
10 LI Yi, WAN De-guang, PEI Jin, CHEN XinChengdu University of Traditional Chinese Medicine (Chengdu,610075,China);Study on Poria on Liquid Fermentation Conditions[J];Journal of Chengdu Unversity of Tarditional Chinese Medicine;2005-01
【Secondary References】
Chinese Journal Full-text Database 1 Hits
1 HOU Juan1,YANG Feng-rui2,CUI Zhi-qing21 Department of Pharmacology,Tianjin Institute Drug Control,2 Department of Pharmacology,Tianjin Medical University,Tianjin 300070,China;Protective effects of Yiqihuoxuechengqi Mixture on intestinal epithelium mucosae in incomplete intestinal obstructive rat model[J];Chinese Journal of Clinical Pharmacology and Therapeutics;2008-09
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