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《Anhui Medical and Pharmaceutical Journal》 2006-05
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Effect of compound astragalus extract on TNFα、NO and IL-1 secreted by rat peritoneal macrophages induced by lipopolysaccharide

LU Jing-tao,CHEN Min-zhu(Institute of Clinical Pharmacology,Anhui Medical University,Hefei 230032)  
Aim To study effect of compound astragalus extract(CAE)on TNFα,IL-1 and NO secreted by normal rat peritoneal macrophages(PM_(Φ)).Methods Rat peritoneal macrophages was stimulated with 10 mg·L~(-1 )LPS in vitro.TNFα was measured by assay of cytotoxicity against L929 cells ,The concentration of NO was determined by Griess assay,activity of IL-1 was assayed by \TdR incorporation assay.Results CAE could markedly inhibit production of TNFα,IL-1 and NO from normal rats PM_(Φs) induced by LPS.Conclusion Inhibiting directly secretion of TNFα,IL-1 and NO produced by PM_Φs might be one of the mechanisms of hepatoprotective effect of CAE.
【CateGory Index】: R285
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