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Effects of water extracts from coix lachryma-jobi on immune function in immune suppressive mice

YE Min(Dept.of Pharmacy,The Central Hospital of Ma'anshan,Ma'anshan,Anhui Province,243000)  
AimTo investigate the effects of water extracts from Coix lachryma-jobion immune regulatory function in immune depressive mice.MethodsAfter the experimental mice treated with cyclophosphamide(CY) to create the mice immunity functional disorder model,the mice of 3 groups were treated with continually oral administrated water extracts from Coix lachryma-jobi(WECL)by 10,5,2.5 g·kg~-~1 for 10 days.The mice immunity organ weight,the number of blood cell,phagocytic percentage and phagocytic index in peritoneal macrophages(PMφ),the esterase positive rate of T lymphocyte and content of serum hemolysin HC_(50) in mice immunized with SRBC were observed.ResultsWECL capsule could obviously antagonist the immune organ weight loss and decrement of the number of blood cell induced by cyclophosphamide(Cy),significantly increase phagocytic percentage and phagocytic index in PMφ,and markedly increase the contents of serum hemolysin and obviously promote the esterase positive rate of T lymphocyte.ConclusionWECL can enhance the immune function obviously,including the changes of humoral immunity,cellular immunity and nonspecific immunity.
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