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《Anhui Medical and Pharmaceutical Journal》 2006-12
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Determination of chlorphenamine maleate and diclofenac sodium in compound diclofenac sodium chlorphenamine maleate tablets by HPLC

ZHONG Huai-bin,SUN Ling-yun,YING Ying(Anhui Provincial Institute for Drug Control,Hefei 230051,China)  
Aim To establish the method for determination of chlorphenamine maleate and diclofenac sodium in compound diclofenac sodium chlorphenamine maleate tablets by HPLC.Methods ODS-C_1_8 column(250 nm×4.6 mm)was used,the detection wavelength at 262 nm,1-Heptanesulfonic acid Sodium solution-methanol-acetonitrile(25∶30∶18)as the mobile phase.Results The calibration curvers were linear in the range of 100.8~ 504.0 mg·L~(-1) for chlorphenamine maleate(r=0.9999) and 16.63~83.15 mg·L~(-1)for diclofenac Sodium(r=0.9997).The average recovery was 100.7% and 98.8% respectively.Conclusions The method is simple,accurate,and well reproducible.It can be used for content determination of chlorphenamine maleate and diclofenac sodium in compound diclofenac sodium chlorphenamine maleate tablets.
【CateGory Index】: R927
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